Comparison of "sandwich chemo-radiotherapy" and six cycles of chemotherapy followed by adjuvant radiotherapy in patients with stage IIIC endometrial cancer: a single center experience

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dc.contributor.authorDogan, Nasuh Utku
dc.contributor.authorYavas, Guler
dc.contributor.authorYavas, Cagdas
dc.contributor.authorAta, Ozlem
dc.contributor.authorYilmaz, Setenay Arzu
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T18:41:19Z
dc.date.available2020-03-26T18:41:19Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo compare "sandwich chemo-radiotherapy" with six cycles of chemotherapy followed by adjuvant radiotherapy with respect to tolerability and acute toxicity. Twenty-five women with surgically staged IIIC endometrial cancer were included. Treatment consisted of either three cycles of paclitaxel (175 mg/mA(2)) and carboplatin (AUC 6) on a q21-day schedule followed by irradiation (45-50.4 Gy) or six cycles of the same chemotherapy followed by radiotherapy. Acute toxicity related to either chemotherapy or radiotherapy was evaluated. Median age was 61.5 years (range 36-83 years). Eleven patients had sandwich chemo-radiotherapy, and the other 14 patients had 6 cycles of chemotherapy followed by radiotherapy. Three out of the five patients who could not complete all the cycles in the sandwich chemo-radiotherapy group had pelvic and para-aortic radiotherapy. Acute radiotherapy related grade 1-2 gastrointestinal system (GIS) and genitourinary system (GUS) toxicities were observed in 72.8 and 63.6 % of patients, respectively, for sandwich group. Undesired treatment breaks in the course of radiotherapy were observed in six patients for sandwich chemo-radiotherapy and in one patient receiving six cycles of chemotherapy followed by radiotherapy. All the patients who had undesired treatment breaks in the sandwich chemo-radiotherapy group had pelvic and para-aortic radiotherapy. Sandwich chemo-radiotherapy seems to be more toxic particularly for patients who had pelvic and para-aortic irradiation. Therefore, it might be more convenient to delay radiotherapy after six cycles of chemotherapy for patients with the indication of pelvic para-aortic radiotherapy.en_US
dc.identifier.doi10.1007/s00404-013-2817-9en_US
dc.identifier.endpage850en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issue4en_US
dc.identifier.pmid23553195en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage845en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-013-2817-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29309
dc.identifier.volume288en_US
dc.identifier.wosWOS:000324635900018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndometrial canceren_US
dc.subjectSandwich chemotherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectAcute toxicityen_US
dc.titleComparison of "sandwich chemo-radiotherapy" and six cycles of chemotherapy followed by adjuvant radiotherapy in patients with stage IIIC endometrial cancer: a single center experienceen_US
dc.typeArticleen_US

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