Survey of Phytochemical Composition and Biological Effects of Three Extracts from a Wild Plant (Cotoneaster nummularia Fisch et Mey.): A Potential Source for Functional Food Ingredients and Drug Formulations

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorUysal, Ahmet
dc.contributor.authorGüneş, Erdoğan
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T18:58:33Z
dc.date.available2020-03-26T18:58:33Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was focused on the analysis of the phenolic content, antioxidant, antibacterial, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase activity of three solvent extracts from Cotoneaster nummularia. Moreover, water extract was tested in terms of mutagenic/anti-mutagenic effects. The antioxidant activities of these extracts were evaluated by DPPH, ABTS, O-2, metal chelating, phosphomolybdenum, beta-carotene/linoleic acid, ferric and cupric reducing power assays. Enzyme inhibitory activities were also examined with colorimetric methods. Generally, methanol and water extracts exhibited excellent biological activities. These extracts were rich in phenolic and flavonoid content. Furthermore, Cotoneaster extracts indicated appreciable antibacterial properties against human pathogen strains. HPLC analysis showed that ferulic acid, chlorogenic acid, (-) - epicatechin and (+)-catechin were the major phenolics in extracts tested. These data offer that these extracts from C. nummularia may be considered as a potential source of biological agents for developing functional foods or drug formulations.en_US
dc.identifier.doi10.1371/journal.pone.0113527en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue11en_US
dc.identifier.pmid25409171en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0113527
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31164
dc.identifier.volume9en_US
dc.identifier.wosWOS:000345533200134en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.relation.ispartofPLOS ONEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSurvey of Phytochemical Composition and Biological Effects of Three Extracts from a Wild Plant (Cotoneaster nummularia Fisch et Mey.): A Potential Source for Functional Food Ingredients and Drug Formulationsen_US
dc.typeArticleen_US

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