The relationship between KRAS LCS6 polymorphism and endometrium cancer

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dc.contributor.authorCintesun, Feyza Nur Incesu
dc.contributor.authorSecilmis Kerimoglu, Ozlem
dc.contributor.authorCintesun, Ersin
dc.contributor.authorNergiz, Suleyman
dc.contributor.authorAcar, Hasan
dc.contributor.authorÇelik, Çetin
dc.date.accessioned2020-03-26T20:19:33Z
dc.date.available2020-03-26T20:19:33Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate the relationship between KRAS LCS6 mutation and endometrial cancer (EC). The study included 105 patients who had hysterectomy for benign reasons and 99 EC patients. The patients with Type 1 EC were classified according to histological properties, cancer stage, grade, tumour dimension, myometrial invasion (MMI), lymphovascular invasion (LVI), cytology, and number of positive lymph nodes. KRAS LCS6 mutation was examined in blood samples taken from all patients in both groups. No statistically significant difference was determined between the EC patients and the control group in demographic features. Weight and the Body Mass Index (BMI) values were higher in EC group (p < .001). While the incidence of this polymorphism is 5.8% throughout the world, the polymorphism rate was found to be 16.2% in the EC group and 12.4% in the control group, with no statistically significant difference determined (p > .05). Despite the higher rate of LCS6 polymorphism incidence in EC patients in this study conducted on a relatively large sample, there was not found to be a statistically significant difference in comparison with the control group. In addition, the presence of LCS6 polymorphism was not determined to have an effect on EC histopathological characteristics.Impact statement What is already known on this subject? Endometrial cancer (EC) is a genital system cancer which is one of the most widespread gynecological cancers seen in the USA and other developed countries, In EC, the most frequently seen gene mutations are PTEN tumour suppressor gene, KRAS, beta 1 catenin, BCL-2, CTNNB and P53 mutations. KRAS LCS6(let-7 miRNA binding region polymorphism) polymorphism has a worldwide incidence of 5.8% (Chin et al. 2008).There are studies shown that KRAS LCS6 polymorphism has an effect on developing EC (Lee et al. 2014), ovarian cancer(Ratner et al. 2010)and endometriosis in women (Grechukhina et al. 2012). What do the results of this study add? In our study, LCS6 located on KRAS 3'-UTR was found at the rate of 16.2% in Type 1 EC patients. This increase is noticeable when it is considered that the incidence of this polymorphism is 5.8% in the general population. The results of the current study supports the preliminary findings of Lee et al.en_US
dc.description.sponsorshipSelcuk University Scientific Projects fundSelcuk Universityen_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Projects fund.en_US
dc.identifier.citationCintesun, F.N.I., Secilmis Kerimoglu, O., Cintesun, E., Nergiz, S., Acar, H., Çelik, Ç. (2019). The Relationship Between KRAS LCS6 Polymorphism and Endometrium Cancer. Journal of Obstetrics and Gynaecology, 40,(7), 988-993.
dc.identifier.doi10.1080/01443615.2019.1678576en_US
dc.identifier.issn0144-3615en_US
dc.identifier.issn1364-6893en_US
dc.identifier.pmid31790621en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2019.1678576
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38317
dc.identifier.wosWOS:000500113500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSecilmis Kerimoglu, Ozlem
dc.institutionauthorCintesun, Ersin
dc.institutionauthorNergiz, Suleyman
dc.institutionauthorAcar, Hasan
dc.institutionauthorÇelik, Çetin
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGeneticen_US
dc.subjectmutationen_US
dc.subjectKRAS LCS6en_US
dc.subjectendometrium canceren_US
dc.titleThe relationship between KRAS LCS6 polymorphism and endometrium canceren_US
dc.typeArticleen_US

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