The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcet's disease

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dc.contributor.authorDursun, Ahmet
dc.contributor.authorÇiçek, Salih
dc.contributor.authorKeni, Fatih M.
dc.contributor.authorÇelik, Sevim Karakaş
dc.contributor.authorSezer, Tuna
dc.contributor.authorAltınyazar, Hilmi Cevdet
dc.date.accessioned2020-03-26T18:58:39Z
dc.date.available2020-03-26T18:58:39Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: Behcet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behcet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated. Patients and Methods: Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method. Results: There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD. Conclusion The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.en_US
dc.identifier.endpage274en_US
dc.identifier.issn0001-527Xen_US
dc.identifier.issn1734-154Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid24936519en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31223
dc.identifier.volume61en_US
dc.identifier.wosWOS:000338392800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACTA BIOCHIMICA POLONICAen_US
dc.relation.ispartofACTA BIOCHIMICA POLONICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPON1 geneen_US
dc.subjectPolymorphismen_US
dc.subjectBehcet's diseaseen_US
dc.titleThe relation of PON1-L55M gene polymorphism and clinical manifestation of Behcet's diseaseen_US
dc.typeArticleen_US

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