Tissue oxidative stress in non small cell lung cancer

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dc.contributor.authorAydin, Leyla Y.
dc.contributor.authorKiyici, Aysel
dc.contributor.authorBerktas, Bahadir M.
dc.contributor.authorBerkoglu, Mine
dc.contributor.authorYucel, Dogan
dc.date.accessioned2020-03-26T17:40:57Z
dc.date.available2020-03-26T17:40:57Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: As the leading cause of adult mortality for many countries, lung cancer was considered to be related with free radical injury. We aimed to investigate if the oxidative stress is increased or not in malignant tissues, compared to the normal ones in non small cell lung cancer. Methods: We compared malignant and normal lung tissues for their malondialdehyde, total thiol and vitamin E contents in 35 smoker patients with non small cell lung cancer. Results: There was no significant difference between malignant and normal tissues for malondialdehyde and total thiol concentrations (p>0.05). However, vitamin E contents of the malignant tissues were significantly higher than the normal tissues (p<0.05). Conclusion: Similar malondialdehyde levels in malignant and normal tissues suggest that cigarette smoke induces a diffuse increase of free radical formation in lung tissue, rather than a focal response. In malignant tissues, malondialdehyde formation might be prevented by high tissue levels of vitamin E.en_US
dc.description.sponsorshipLilly Companyen_US
dc.description.sponsorshipWe thank Lilly Company for their grant in supplementation of Vitamin E analysis kit.en_US
dc.identifier.endpage219en_US
dc.identifier.issn0250-4685en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23987
dc.identifier.volume34en_US
dc.identifier.wosWOS:000274244400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectoxidative stressen_US
dc.subjectnon small cell lung canceren_US
dc.subjectvitamin Een_US
dc.titleTissue oxidative stress in non small cell lung canceren_US
dc.typeArticleen_US

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