Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness

dc.contributor.authorOzturk, Banu Turgut
dc.contributor.authorBozkurt, Banu
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorOkka, Mehmet
dc.contributor.authorKamis, Umit
dc.contributor.authorGunduz, Kemal
dc.date.accessioned2020-03-26T17:38:22Z
dc.date.available2020-03-26T17:38:22Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To investigate the role of serum inflammatory cytokines and vascular endothelial growth factor (VEGF) in diabetic retinopathy (DR) and evaluate their relationship with macular thickness measurements obtained with optical coherence tomography (OCT). Methods: The study enrolled 28 healthy subjects (Group 1), 31 patients without DR (Group 2), 49 patients with nonproliferative DR (Group 3), and 46 patients with proliferative DR (Group 4). Macular profile was assessed with Stratus OCT-3 and the serum concentrations of VEGF and interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), macrophage inflammatory protein (MIP-1 alpha), monocyte chemoattractant protein (MCP-1), and epidermal growth factor (EGF) were measured using multiplex bead immunoassay. Results: The median value of the visual acuity was 20/20 (Groups 1 and 2), and 20/100 (Group 3), and 20/125 (Group 4). The median value of central subfield macular thickness was estimated as 165.50 mu m in Group 1, 202.5 mu m in Group 2, 318 mu m in Group 3, and 310 mu m in Group 4. The median serum VEGF level, which was 98.20 pg/ml in Group 1, demonstrated a progressive rise to 125.37 pg/ml in Group 2, to 153.07 pg/ml in Group 3, and to 149.12 pg/ml in Group 4. Statistical significance was found between all groups (p<0.05) except between Groups 3 and 4 (p=0.87). The median levels of IL-1 alpha and IL-6 were zero in all groups. The median serum levels of IL-8, IL-10, MIP-1 alpha, and EGF revealed a wide range within each group but no statistical significance between the groups (p>0.05). The median serum levels of IL-8, IL-10, MIP-1 alpha, and EGF revealed a wide range within each group, however, no statistically significant relationship was found between the groups (p>0.05). The median values of the serum MCP-1 concentrations presented a statistically significant rise with the progression of DR (p=0.02). No correlation was found between macular thickness and serum cytokine and VEGF levels (p>0.05). Conclusions: Increased serum levels of VEGF and MCP-1 may act as a key regulator of DR and provide a potential tool for risk assessment in diabetic patients. Further studies that evaluate both vitreous and serum levels in various stages of DR are needed to provide a better understanding of the interaction between systemic and local inflammatory and angiogenic factors.en_US
dc.identifier.endpage1914en_US
dc.identifier.issn1090-0535en_US
dc.identifier.issue203en_US
dc.identifier.pmid19784389en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1906en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23460
dc.identifier.volume15en_US
dc.identifier.wosWOS:000271618200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMOLECULAR VISIONen_US
dc.relation.ispartofMOLECULAR VISIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffect of serum cytokines and VEGF levels on diabetic retinopathy and macular thicknessen_US
dc.typeArticleen_US

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