The effects of zinc and melatonin on muscle ischaemi-reperfusion injury in rat

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dc.contributor.authorÇeler, Mehmet
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorDaşdelen, Derviş
dc.date.accessioned2020-03-26T19:56:15Z
dc.date.available2020-03-26T19:56:15Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIschemia-reperfusion leads to damage in cell or tissue due to insufficient blood flow. The aim of present study was to determine the effect of zinc, melatonin and zinc + melatonin supplementations during 3 weeks on muscle tissue and plasma MDA and GSH levels. This study was performed on 38 male Wistar- Albino rats. Experiments groups were designed as sham-control, ischemia-reperfusion (I/R), zinc + I/R, melatonin + I/R and zinc + melatonin + I/R Ischemiareperfusion was induced by left femoral artery occlusion (1 hour) and reopening (1 hour). At the end of experiments tissue and blood samples were analysed for MDA and GSH. MDA levels were increased, GSH levels decreased in I/R groups. However, zinc and melatonin supplementation inhibited MDA and increased GSH levels in I/R groups. The results of present study show that increased lipid peroxidation in muscle tissue by ischemia-reperfusion may be prevented by zinc and melatonin or zinc plus melatonin supplementation.en_US
dc.description.sponsorshipgrant Selcuk University, Scientific Research Council [13202046]en_US
dc.description.sponsorshipThis study was supported by a grant Selcuk University, Scientific Research Council (Grant Number is 13202046).en_US
dc.identifier.doi10.14715/cmb/2018.64.3.1en_US
dc.identifier.endpage4en_US
dc.identifier.issn0145-5680en_US
dc.identifier.issn1165-158Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid29506623en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.14715/cmb/2018.64.3.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37034
dc.identifier.volume64en_US
dc.identifier.wosWOS:000426541100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B ASSOCen_US
dc.relation.ispartofCELLULAR AND MOLECULAR BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectMuscleen_US
dc.subjectZincen_US
dc.subjectMelatoninen_US
dc.subjectFree radicalen_US
dc.titleThe effects of zinc and melatonin on muscle ischaemi-reperfusion injury in raten_US
dc.typeArticleen_US

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