Endothelin Receptor Blockade with Tezosentan Ameliorates Myocardial Injury Induced by Abdominal Aortic Ischemia-Reperfusion

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dc.contributor.authorNarin, Cueneyt
dc.contributor.authorKiris, Ilker
dc.contributor.authorGulmen, Senol
dc.contributor.authorToy, Hatice
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorSutcu, Recep
dc.date.accessioned2020-03-26T17:26:48Z
dc.date.available2020-03-26T17:26:48Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEndothelin is both a potent vasoconstrictor and an important mediator of ischemia-reperfusion (IR) injury. Therefore, the role of endothelin receptor antagonism in IR-induced-tissue injury carries great interest. Here, we examined the effect of tezosentan, a nonselective antagonist for endothelin receptors, on myocardial injury induced by abdominal aortic IR, which represents a model of the IR injury in distant organs frequently occurred after vascular surgery. Thirty-two Wistar rats were randomized into four groups (17 = 8) as follows: control (sham laparotomy), aortic IR (120 min ischemia and 120 min reperfusion), aortic IR + tezosentan (10 mg/kg intravenous injection before ischemia plus continuous intravenous infusion of 1 mg/kg/hr during the IR injury), and control + tezosentan. Biochemical analysis showed that aortic IR significantly increased (p < 0.05 vs control) the plasma levels of troponin-I, interleukin-6 and tumor necrosis factor-alpha, and the myocardial tissue levels of malondialdehyde, superoxide dismutase and catalase, whereas tezosentan significantly decreased these same factors (p < 0.05 vs aortic IR). Histological evaluation also showed that aortic IR significantly increased (p < 0.05 vs control) myocardial disorganization, myofiber swelling and myofiber cosinophilia in myocardial tissue samples, whereas tezosentan significantly decreased these factors (p < 0.05 vs aortic IR). These results indicate that tezosentan has protective effects against myocardial injury induced by abdominal aortic IR in rats. We propose that the mechanisms underlying this protective effect of tezosentan involves the reduction of oxidative stress and subsequent lipid peroxidation, the inhibition of systemic inflammatory response, and acting cytoprotective on myocytes after aortic IR.en_US
dc.description.sponsorshipActelion Ltd, Turkeyen_US
dc.description.sponsorshipThe authors thank Marc Iglarz (Actelion Pharmaceuticals Ltd, Allschwill, Switzerland) for generously giving tezosentan. The commercial kits for the biochemical analyses were sponsored by Actelion Ltd, Turkey.en_US
dc.identifier.doi10.1620/tjem.216.267en_US
dc.identifier.endpage276en_US
dc.identifier.issn0040-8727en_US
dc.identifier.issn1349-3329en_US
dc.identifier.issue3en_US
dc.identifier.pmid18987461en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://dx.doi.org/10.1620/tjem.216.267
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22376
dc.identifier.volume216en_US
dc.identifier.wosWOS:000260913000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTOHOKU UNIV MEDICAL PRESSen_US
dc.relation.ispartofTOHOKU JOURNAL OF EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAbdominal aortic surgeryen_US
dc.subjectreperfusion injuryen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectacute-phase reactionen_US
dc.subjectendothelin-1en_US
dc.titleEndothelin Receptor Blockade with Tezosentan Ameliorates Myocardial Injury Induced by Abdominal Aortic Ischemia-Reperfusionen_US
dc.typeArticleen_US

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