Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors

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dc.contributor.authorGergerlioğlu, Hasan Serdar
dc.contributor.authorÖz, Mehmet
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorYerlikaya, Fatma Hümeyra
dc.date.accessioned2020-03-26T19:23:59Z
dc.date.available2020-03-26T19:23:59Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAims: Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and memory in theHFD-induced cognitive deficits, but the exact mechanismis still not clearly understood. Therefore, the present study aimed to clarify the effects of the EE on spatial memory in WD-fed rats, and to analyze the potential role of corticosteroid receptors in the EE conditioning. Main methods: MaleWistar albino rats were housed in either an enriched or standard environment and fed with the HFD (35% of energy as fat), HSU (100% of carbohydrate as sucrose) or standard rat chowfor 4 weeks. Weused the Morris' water maze test (MWM) to assess the learning and memory performance, and measured plasma levels of corticosterone (CORT) and adrenocorticotropic hormone (ACTH), as well as glucocorticoid (GR) and mineralocorticoid receptor (MR) levels in the hippocampus. Key findings: The results showed that HFD-fed rats displayed poorer learning and memory performance evaluated with MWM than controls. The EE reversed the cognitive deficits caused by the HFD. In addition, the EE resulted in an increase of GR and MR levels without affecting plasma CORT and ACTH concentrations. Significance: Based on these findings, it could be suggested that the EE plays an important role in amelioration of the HFD-induced cognitive impairments, but this intervention is independent of the hypothalamic-pituitaryadrenal axis and hippocampal corticosteroid receptor levels. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination Unit, Konya, TurkeySelcuk University [14401047]en_US
dc.description.sponsorshipThis study has been supported by Selcuk University Scientific Research Projects Coordination Unit, Konya, Turkey (Project no.: 14401047). We would like to express our sincere thanks to Dervis Dasdelen, M.D. for his precious suggestions and help in constructing the enriched environment objects, and to Muhammed Ikbal ALP, M.D. for his technical support.en_US
dc.identifier.doi10.1016/j.lfs.2016.02.011en_US
dc.identifier.endpage285en_US
dc.identifier.issn0024-3205en_US
dc.identifier.issn1879-0631en_US
dc.identifier.pmid26855000en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.lfs.2016.02.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33548
dc.identifier.volume148en_US
dc.identifier.wosWOS:000371789300034en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofLIFE SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectWestern dieten_US
dc.subjectEnriched environmenten_US
dc.subjectCognitive functionen_US
dc.subjectWater mazeen_US
dc.subjectGlucocorticoid receptoren_US
dc.subjectMineralocorticoid receptoren_US
dc.titleEnvironmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptorsen_US
dc.typeArticleen_US

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