Comprehensive study of mtDNA among Southwest Asian dogs contradicts independent domestication of wolf, but implies dog-wolf hybridization

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dc.contributor.authorArdalan, Arman
dc.contributor.authorKluetsch, Cornelya F. C.
dc.contributor.authorZhang, Ai-bing
dc.contributor.authorErdogan, Metin
dc.contributor.authorUhlen, Mathias
dc.contributor.authorHoushmand, Massoud
dc.contributor.authorTepeli, Cafer
dc.date.accessioned2020-03-26T18:14:01Z
dc.date.available2020-03-26T18:14:01Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractStudies of mitochondrial DNA (mtDNA) diversity indicate explicitly that dogs were domesticated, probably exclusively, in southern East Asia. However, Southwest Asia (SwAsia) has had poor representation and geographical coverage in these studies. Other studies based on archaeological and genome-wide SNP data have suggested an origin of dogs in SwAsia. Hence, it has been suspected that mtDNA evidence for this scenario may have remained undetected. In the first comprehensive investigation of genetic diversity among SwAsian dogs, we analyzed 582 bp of mtDNA for 345 indigenous dogs from across SwAsia, and compared with 1556 dogs across the Old World. We show that 97.4% of SwAsian dogs carry haplotypes belonging to a universal mtDNA gene pool, but that only a subset of this pool, five of the 10 principal haplogroups, is represented in SwAsia. A high frequency of haplogroup B, potentially signifying a local origin, was not paralleled with the high genetic diversity expected for a center of origin. Meanwhile, 2.6% of the SwAsian dogs carried the rare non-universal haplogroup d2. Thus, mtDNA data give no indication that dogs originated in SwAsia through independent domestication of wolf, but dog-wolf hybridization may have formed the local haplogroup d2 within this region. Southern East Asia remains the only region with virtually full extent of genetic variation, strongly indicating it to be the primary and probably sole center of wolf domestication. An origin of dogs in southern East Asia may have been overlooked by other studies due to a substantial lack of samples from this region.en_US
dc.description.sponsorshipNational Institute of Genetic Engineering and Biotechnology (NIGEB) of Iran; Swedish Research CouncilSwedish Research Council; OE and Edla Johanssons Scientific Foundation; Wenner-Gren Foundations; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundationen_US
dc.description.sponsorshipFunded by the National Institute of Genetic Engineering and Biotechnology (NIGEB) of Iran, grants from the Swedish Research Council, OE and Edla Johanssons Scientific Foundation, and the Wenner-Gren Foundations. Peter Savolainen is a Royal Swedish Academy of Sciences Research Fellow supported by a grant from the Knut and Alice Wallenberg Foundation.en_US
dc.identifier.doi10.1002/ece3.35en_US
dc.identifier.endpage385en_US
dc.identifier.issn2045-7758en_US
dc.identifier.issue3en_US
dc.identifier.pmid22393507en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ece3.35
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26270
dc.identifier.volume1en_US
dc.identifier.wosWOS:000312441000009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofECOLOGY AND EVOLUTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCanis familiarisen_US
dc.subjectdomesticationen_US
dc.subjectfertile crescenten_US
dc.subjecthybridizationen_US
dc.subjectmitochondrial DNAen_US
dc.titleComprehensive study of mtDNA among Southwest Asian dogs contradicts independent domestication of wolf, but implies dog-wolf hybridizationen_US
dc.typeArticleen_US

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