The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus

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dc.contributor.authorArıbaş, Alpay
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorTekinalp, Mehmet
dc.contributor.authorAkıllı, Hakan
dc.contributor.authorAlibaşiç, Hayruddin
dc.contributor.authorYıldırım, Serkan
dc.contributor.authorGündüz, Mehmet
dc.date.accessioned2020-03-26T19:07:38Z
dc.date.available2020-03-26T19:07:38Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/Aims: Poor sleep quality (SQ) is associated with increased cardiovascular mortality and morbidity. Additionally, asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular mortality and morbidity. However, no sufficient data regarding the relationship between ADMA levels and SQ have been reported. The goal of the current study was to evaluate the association between SQ and ADMA levels in normotensive patients with type 2 diabetes mellitus. Methods: The study participants consisted of 78 normotensive type 2 diabetics. The SQ of all participants was assessed using the Pittsburgh Sleep Quality Index (PSQI). Patients with a global PSQI score > 5 were defined as "poor sleepers." Factors associated with poor SQ were analyzed using a multiple regression model. Serum ADMA levels were measured using high performance liquid chromatography. Results: The median ADMA levels of the poor sleepers were increased compared with patients defined as good sleepers (5.5 [4.2 to 6.6] vs. 4.4 [2.9 to 5.4], p < 0.01, respectively). However, the L-arginine/ADMA ratio was decreased in poor sleepers (p < 0.01). Global PSQI scores were positively correlated with ADMA levels (p < 0.01) and negatively correlated with the L-arginine/ADMA ratio (p = 0.02). ADMA levels were correlated with sleep latency (p < 0.01) and sleep efficiency (p = 0.01). Logistic regression analysis showed that ADMA levels (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.16 to 2.44; p = 0.01) and body mass index (OR, 1.15; 95% CI, 1.01 to 1.31; p = 0.04) were associated with poor SQ independently of glomerular filtration rate, sex, age, duration of diabetes, hemoglobin A1c, total cholesterol, and systolic blood pressure. Conclusions: Self-reported SQ was independently associated with ADMA levels in normotensive patients with diabetes mellitus.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects FundSelcuk Universityen_US
dc.description.sponsorshipThis project was supported by Selcuk University Scientific Research Projects Fund.en_US
dc.identifier.doi10.3904/kjim.2015.30.3.316en_US
dc.identifier.endpage324en_US
dc.identifier.issn1226-3303en_US
dc.identifier.issn2005-6648en_US
dc.identifier.issue3en_US
dc.identifier.pmid25995662en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://dx.doi.org/10.3904/kjim.2015.30.3.316
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32681
dc.identifier.volume30en_US
dc.identifier.wosWOS:000353933700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKOREAN ASSOC INTERNAL MEDICINEen_US
dc.relation.ispartofKOREAN JOURNAL OF INTERNAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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