Effect of gamma-hydroxybutyric acid on tissue Na+,K+-ATPase levels after experimental head trauma

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dc.contributor.authorYosunkaya, A
dc.contributor.authorUstun, ME
dc.contributor.authorBariskaner, H
dc.contributor.authorTavlan, A
dc.contributor.authorGurbilek, M
dc.date.accessioned2020-03-26T16:48:15Z
dc.date.available2020-03-26T16:48:15Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: A failure of the Na+,K+-ATPase activity (which is essential for ion flux across the cell membranes) occurs in many pathological conditions and may lead to cell dysfunction or even cell death. By altering the concentration of specific opioid peptides, gamma-hydroxybutyric acid (GHB) may change ion flux across cell membranes and produce the 'channel arrest' which we assumed will inhibit the failure of Na+,K+-ATPase activity and therefore lead to energy conservation and cell protection. Therefore we planned this study to see the effects of GHB at two different doses on Na+,K+-ATPase activity in an experimental head trauma model. Methods: Forty New Zealand rabbits were divided equally into four groups: group I was the sham-operated group, group II (untreated group), group III received head trauma and intravenous (i.v.) 500 mg/kg GHB and group IV received head trauma and i.v. 50 mg/kg GHB. Head trauma was delivered by performing a craniectomy over the right hemisphere and dropping a weight of 10 g from a height of 80 cm. The non-traumatized (left) side was named as 'a' and the traumatized (right) side as 'b'. One hour after the trauma in groups II and III and craniotomy in group I, brain cortices were resected from both sides and in group I only from the right side was the tissue Na-K-ATPase activity determined. Results: The mean +/- SD of Na+,K+-ATPase levels of each group are as follows: group I - 5.97 +/- 0.55; group IIa - 3.90 +/- 1.08; group IIb - 3.58 +/- 0.90; group IIIa - 5.53 +/- 0.60; group IIIb - 5.33 +/- 0.88; group IVa - 5.05 +/- 0.72; group IVb - 4.93 +/- 0.67. The Na+,K+-ATPase levels of group IIa, IIb, IVa and IVb were significantly different from group S (P < 0.05). There were also significant differences between group IIa and groups IIIa and IVa; group IIb and groups IIIb and IVb (P < 0.05). Conclusions: We conclude that GHB is effective in suppressing the decrease in Na+,K+-ATPase levels in brain tissue at two different dose schedules after head trauma.en_US
dc.identifier.doi10.1111/j.1399-6576.2004.00384.xen_US
dc.identifier.endpage636en_US
dc.identifier.issn0001-5172en_US
dc.identifier.issn1399-6576en_US
dc.identifier.issue5en_US
dc.identifier.pmid15101861en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage631en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1399-6576.2004.00384.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19007
dc.identifier.volume48en_US
dc.identifier.wosWOS:000220978400015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofACTA ANAESTHESIOLOGICA SCANDINAVICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgamma-hydroxybutyric aciden_US
dc.subjecthead traumaen_US
dc.subjectNa+K+-ATPaseen_US
dc.titleEffect of gamma-hydroxybutyric acid on tissue Na+,K+-ATPase levels after experimental head traumaen_US
dc.typeArticleen_US

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