Salvage Stereotactic Body Radiosurgery in the Management of Recurrent Gynecological Cancer

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dc.contributor.authorYazici, Gozde
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorOzyigit, Gokhan
dc.contributor.authorYavas, Guler
dc.contributor.authorAyhan, Ali
dc.contributor.authorGurkaynak, Murat
dc.contributor.authorYildiz, Ferah
dc.date.accessioned2020-03-26T18:43:17Z
dc.date.available2020-03-26T18:43:17Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLocal tumor persistence in the pelvis is the major cause of death in patients with recurrent gynecological cancer. Pelvic exenteration has been the only treatment option providing a chance for cure in selected patients. The aim of this study is to analyze the efficacy of stereotactic body radiosurgery (SBRS) in patients with recurrent gynecological cancer. Sixteen patients treated with SBRS were analyzed retrospectively. The majority of the patients had cervical cancer. Eleven patients had a history of prior radiotherapy either as postoperative adjuvant external beam radiotherapy (EBRT) with a median dose of 50.4 Gy (range 45-60 Gy) or definitive chemoradiotherapy as EBRT and high dose rate brachytherapy with a dose of 85-90 Gy low dose rate equivalent to point A. The prescribed dose of SBRS was 15-40 Gy (mean 26.6 Gy) in 3-5 fractions. Five patients with no prior radiotherapy received additional EBRT before SBRS. The median follow-up in all patients is 12 months (range 3-36 months). Six patients (37.5%) showed complete radiological and functional response to salvage SBRS. Six patients (37.5%) showed partial response and 2 (12.5%) showed stable disease. One and 2 year overall survival rates are 60.3% and 40.2% respectively. Progression free survival is 59%. All patients with complete response after SBRS are alive with no evidence of disease with a median follow up time of 20 months. SBRS is a promising treatment modality with high local Control and reasonable complication rates in selected patients with recurrent gynecological cancer.en_US
dc.description.sponsorshipHacettepe UniversityHacettepe University [1 05 A 101 009]en_US
dc.description.sponsorshipThis study is supported by Hacettepe University Research Grant 1 05 A 101 009en_US
dc.identifier.doi10.4999/uhod.12040en_US
dc.identifier.endpage12en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://dx.doi.org/10.4999/uhod.12040
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29801
dc.identifier.volume23en_US
dc.identifier.wosWOS:000317021900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCyberknifeen_US
dc.subjectRadiotherapyen_US
dc.subjectRecurrent gynecological canceren_US
dc.subjectSalvageen_US
dc.subjectStereotactic radiosurgeryen_US
dc.titleSalvage Stereotactic Body Radiosurgery in the Management of Recurrent Gynecological Canceren_US
dc.typeArticleen_US

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