Analysis of 24-hour heart rate variations in patients with epilepsy receiving antiepileptic drugs

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dc.contributor.authorYildiz, Gulce Unal
dc.contributor.authorDogan, Ebru Apaydin
dc.contributor.authorDogan, Umuttan
dc.contributor.authorTokgoz, Osman Serhat
dc.contributor.authorOzdemir, Kurtulus
dc.contributor.authorGenc, Bulent Oguz
dc.contributor.authorIlhan, Nurhan
dc.date.accessioned2020-03-26T18:13:46Z
dc.date.available2020-03-26T18:13:46Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The goal of the study described here was to evaluate interictal heart rate variability (HRV) in young patients with epilepsy, a patient population in whom sudden unexpected death in epilepsy (SUDEP) is known to be more common. Methods: Twenty-four-hour ambulatory ECG Holter recordings of 37 patients (15-40 years old) and 32 healthy controls were compared. Results: All of the time domain indices (SDNN, SDANN, RMSSD, and HRV triangular index) were significantly suppressed (P < 0.001), and there was a marked reduction in parasympathetic tone (reduced HFnu, P < 0.001) and an increase in sympathetic tone (increased LFnu and LF/HF ratio, P < 0.001) in the patient group. Stepwise linear regression analysis revealed that polytherapy and epilepsy duration > 10 years were independent variables associated with a reduction in SDNN. Conclusion: Our data suggest that the major determinants of suppressed SDNN are polytherapy and epilepsy duration > 10 years. Analysis of spectral measures of frequency domain indices suggests that an increased sympathetic tone in association with a decreased parasympathetic tone may constitute the mechanism underlying SUDEP in young people with epilepsy. (C)2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.yebeh.2010.12.001en_US
dc.identifier.endpage354en_US
dc.identifier.issn1525-5050en_US
dc.identifier.issn1525-5069en_US
dc.identifier.issue2en_US
dc.identifier.pmid21216204en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.yebeh.2010.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26134
dc.identifier.volume20en_US
dc.identifier.wosWOS:000287833700032en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofEPILEPSY & BEHAVIORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject24-hour electrocardiogramen_US
dc.subjectHeart rate variabilityen_US
dc.subjectSudden unexpected death in epilepsyen_US
dc.subjectEpilepsyen_US
dc.subjectYoung adultsen_US
dc.titleAnalysis of 24-hour heart rate variations in patients with epilepsy receiving antiepileptic drugsen_US
dc.typeArticleen_US

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