Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone

Basit Öğe Kaydı
dc.contributor.authorUnver Dogan, Nadire
dc.contributor.authorUysal, Ismihan Ilknur
dc.contributor.authorFazliogullari, Zeliha
dc.contributor.authorKarabulut, Ahmet Kagan
dc.contributor.authorAcar, Hasan
dc.date.accessioned2020-03-26T19:24:48Z
dc.date.available2020-03-26T19:24:48Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, it was aimed to investigate the toxic and teratogenic effects of cyclosporine A and tacrolimus and their combinations with prednisolone using an in vitro rat embryo culture technique. Cyclosporine A (4-40 mu g/ml), tacrolimus (1-20 mu g/ml) and combinations of these drugs with prednisolone (20 mu g/ml) at different concentrations were tested. Cyclosporine A and its combination with prednisolone were determined to have toxic effects on embryonic growth after 10 mu g/ml. When used alone, the lowest dose of tacrolimus had embryotoxic effects on the total morphological score and number of somites. It was determined that cyclosporine A caused hematoma at 4 mu g/ml and higher doses, and tacrolimus especially at 20 mu g/ml caused an open neural tube beside hematoma. It was observed that cyclosporine A at 40 g/ml dose initiated apoptotic effects at a very low rate, prednisolone increased this effect, tacrolimus led to excessive apoptosis after 15 mu g/ml, and this effect did not change with prednisolone supplement. We are of the opinion that the doses should be determined carefully when cyclosporine A and tacrolimus are required to be administered to pregnant women with prednisolone combination, as prednisolone increases the toxic effects of cyclosporine A, and increases teratogenic effects of tacrolimus. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Coordinating Office of The Selcuk University, Konya, Turkey [10401120]en_US
dc.description.sponsorshipThis study is supported by The Scientific Research Projects Coordinating Office of The Selcuk University, Konya, Turkey. Project number: 10401120.en_US
dc.identifier.doi10.1016/j.yrtph.2016.03.010en_US
dc.identifier.endpage222en_US
dc.identifier.issn0273-2300en_US
dc.identifier.issn1096-0295en_US
dc.identifier.pmid26993750en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.yrtph.2016.03.010
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33728
dc.identifier.volume77en_US
dc.identifier.wosWOS:000376812900025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofREGULATORY TOXICOLOGY AND PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCyclosporine Aen_US
dc.subjectTacrolimusen_US
dc.subjectPrednisoloneen_US
dc.subjectIn vitro embryo cultureen_US
dc.subjectApoptosisen_US
dc.titleInvestigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisoloneen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu