PLASMA DISPOSITION OF CEFOPERAZONE AFTER SINGLE INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATIONS IN CAMELS (CAMELUS DROMEDARIUS)

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dc.contributor.authorAboubakr, Mohamed
dc.contributor.authorSoliman, Ahmed
dc.contributor.authorUney, Kamil
dc.contributor.authorElmas, Muammer
dc.date.accessioned2020-03-26T19:55:11Z
dc.date.available2020-03-26T19:55:11Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe plasma disposition of cefoperazone was investigated after intravenous (IV) and intramuscular (IM) administrations of 20 mg/kg as a single dose in six camels (Camelus dromedarius) in a crossover design. Blood plasma samples were analysed by high-performance liquid chromatography (HPLC). After IV administration, elimination half-life (t(1/2 beta)), volume of distribution at steady state (V-dss), total body clearance (Cl-tot) and mean residence time (MRT) of cefoperazone were 1.95 h, 0.38 L/kg, 0.17 L/h/kg and 2.16 h, respectively. After IM administration of cefoperazone, peak plasma concentration (C-max) was 21.95 mu g/mL and it was obtained at (t(max)) 1.23 h. Absorption half-life (t(1/2ab)), elimination half-life and mean absorption time were 0.45 h, 2.84 h and 2.07 h, respectively. The bioavailability of cefoperazone was 89.42%. The lack of local reaction or any other adverse effects and the very good bioavailability following IM administration indicate that cefoperazone might be a promising alternative treatment for a variety of infectious diseases in camels.en_US
dc.identifier.doi10.1556/004.2018.039en_US
dc.identifier.endpage450en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issn1588-2705en_US
dc.identifier.issue3en_US
dc.identifier.pmid30264621en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage444en_US
dc.identifier.urihttps://dx.doi.org/10.1556/004.2018.039
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36867
dc.identifier.volume66en_US
dc.identifier.wosWOS:000445898600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO ZRTen_US
dc.relation.ispartofACTA VETERINARIA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCefoperazoneen_US
dc.subjectconcentrationsen_US
dc.subjectbioavailabilityen_US
dc.subjectcamelsen_US
dc.titlePLASMA DISPOSITION OF CEFOPERAZONE AFTER SINGLE INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATIONS IN CAMELS (CAMELUS DROMEDARIUS)en_US
dc.typeArticleen_US

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