Association of the Polymorphisms of Vitamin D Receptor and Aggrecan Genes With Degenerative Disc Disease

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dc.contributor.authorEser, Betül
dc.contributor.authorCora, Tülin
dc.contributor.authorEser, Olcay
dc.contributor.authorKalkan, Erdal
dc.contributor.authorHaktanır, Alpay
dc.contributor.authorErdoğan, Müjgan O.
dc.contributor.authorSolak, Mustafa
dc.date.accessioned2020-03-26T17:47:09Z
dc.date.available2020-03-26T17:47:09Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the association between the polymorphisms of the vitamin D receptor (VDR) and aggrecan genes and degenerative disc disease in young Turkish patients. Aggrecan and VDR proteins are the main components of bone and cartilage. In our study, the polymorphisms of the VDR and aggrecan genes were investigated in a total of 300 individuals regarding disc degeneration and herniation. An association was found in the patients having VDR gene TT, Tt, FF, and Ff genotypes with the protrusion type of disc herniation, whereas the patients having tt and ff genotypes were associated with extrusion/sequestration types of the disease. Also, an association was observed between TT and FF genotypes of the VDR gene and mild forms of disc degeneration; and tt, ff, and Ff genotypes and severe forms of the disease. There was also an association between shorter, normal, and longer alleles of the aggrecan gene and a protrusion type of disc herniation. An association was found between short alleles and multilevel and severe disc degeneration, as well as normal and long alleles and mild disc degeneration. This study revealed that the polymorphisms of the VDR and aggrecan genes are associated with disc degeneration and herniation.en_US
dc.description.sponsorshipAfyon Kocatepe UniversityAfyon Kocatepe University [06.TIP.27]en_US
dc.description.sponsorshipThis work was supported by the research fund of the Afyon Kocatepe University (project 06.TIP.27).en_US
dc.identifier.citationEser, B., Cora, T., Eser, O., Kalkan, E., Haktanır, A., Erdoğan, M. O., Solak, M., (2010). Association of the Polymorphisms of Vitamin D Receptor and Aggrecan Genes With Degenerative Disc Disease. Genetic Testing and Molecular Biomarkers, 14(3), 313-317. Doi: 10.1089/gtmb.2009.0202
dc.identifier.doi10.1089/gtmb.2009.0202en_US
dc.identifier.endpage317en_US
dc.identifier.issn1945-0265en_US
dc.identifier.issue3en_US
dc.identifier.pmid20367178en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://dx.doi.org/10.1089/gtmb.2009.0202
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24636
dc.identifier.volume14en_US
dc.identifier.wosWOS:000279170100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEser, Betül
dc.institutionauthorCora, Tülin
dc.institutionauthorKalkan, Erdal
dc.language.isoenen_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleAssociation of the Polymorphisms of Vitamin D Receptor and Aggrecan Genes With Degenerative Disc Diseaseen_US
dc.typeArticleen_US

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