Phenolic profile and bioactivities of Sideritis perfoliata L.: The plant, its most active extract, and its broad biological properties

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dc.contributor.authorSarıkürkcü, Cengiz
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorMocan, Andrei
dc.contributor.authorZengin, Gökhan
dc.contributor.authorKırkan, Bülent
dc.date.accessioned2020-03-26T20:20:25Z
dc.date.available2020-03-26T20:20:25Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractSideritis, also named "ironwort," "mountain tea," or "shepherd's tea," is a genus of flowering plants used as herbal medicine in traditional Mediterranean-area medicine systems, and these plants are generally consumed as a herbal tea. Its use as herbal tea and in traditional herbal medicine is quite popular. There are currently few studies on Sideritis perfoliata L., and only one reports the use of a liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-ESI-MSn) profile and the content of phenolic compounds without considering a possible correlation with its biological activities. This paper aims to investigate the antioxidant activities by means of several different biological/biochemical assays (radical scavenging, reducing power, ferrous ion chelating, and total antioxidant by phosphomolybdenum and beta-carotene bleaching methods) as well as analyze the enzyme inhibitory activities (against AChE (acetylcholinesterase), BChE (butyrylcholinesterase), tyrosinase, alpha-glucosidase, and alpha-amylase) as well as the total phenolics, flavonoids, and condensed tannins. The reported results on Sideritis perfoliata highlighted that methanol and water extracts generally showed higher radical scavenging and reducing power activities. A similar trend could be observed for phosphomolybdenum and ferrous ion chelating activities. Methanol extracts showed lower activity only for the beta-carotene bleaching assay.en_US
dc.identifier.citationSarıkürkcü, C., Locatelli, M., Mocan, A., Zengin, G., Kırkan, B. (2020). Phenolic Profile and Bioactivities of Sideritis perfoliata L.: The Plant, Its Most Active Extract, and Its Broad Biological Properties. Frontiers in Pharmacology, 10, 1-11.
dc.identifier.doi10.3389/fphar.2019.01642en_US
dc.identifier.issn1663-9812en_US
dc.identifier.pmid32116669en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3389/fphar.2019.01642
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38581
dc.identifier.volume10en_US
dc.identifier.wosWOS:000517469200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.relation.ispartofFRONTIERS IN PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSideritis perfoliataen_US
dc.subjectLC-ESI-MSen_US
dc.subjectMSen_US
dc.subjectPhenolic profileen_US
dc.subjectEnzyme inhibitory activitiesen_US
dc.subjectAntioxidant activitiesen_US
dc.titlePhenolic profile and bioactivities of Sideritis perfoliata L.: The plant, its most active extract, and its broad biological propertiesen_US
dc.typeArticleen_US

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