Malignant glioblastomatous transformation of a low-grade glioma in a child

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dc.contributor.authorUnal, Ekrem
dc.contributor.authorKoksal, Yavuz
dc.contributor.authorCimen, Omer
dc.contributor.authorPaksoy, Yahya
dc.contributor.authorTavli, Lema
dc.date.accessioned2020-03-26T17:27:12Z
dc.date.available2020-03-26T17:27:12Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe term of low-grade glioma addresses a favorable clinical outcome with indolent histological features in general consideration; however, recent studies underline the inconsistency, which originates from the accumulation of different histologic subtypes in this terminology. The malignant transformation of a low-grade glioma is unusual but presents a poor prognosis. We report a case of a 12-year-old boy, who was referred for complaints of recurrent seizures. His physical examination was unremarkable, but it was learned that a peripheral mass lesion located on the left posterior parietal lobe-which had been thought to be a low-grade glioma-had been detected on a magnetic resonance imaging 2 years ago at a different hospital. The patient was then treated with valproate and carbamazepine for the seizures and advised to be followed up without any additional diagnostic and therapeutic studies for his suspected low-grade glioma. A recent magnetic resonance imaging study showed enlargements of the mass and surrounding edema with additional necrosis. Surgical excision of the tumor was performed. After the diagnosis of glioblastoma multiforme, the patient received radiation therapy and chemotherapy with a good clinical recovery without any evidence of residue or recurrence at 12-month follow-up. The first line treatment modality in the management of low-grade glioma-especially in suitable patients-is clearly surgery. The gross total resection guarantees the distinguishing of the histological types of the low-grade gliomas and reflects the biologic behavior of these tumors. Observation without surgery must be reserved for selected unoperable cases.en_US
dc.identifier.doi10.1007/s00381-008-0716-3en_US
dc.identifier.endpage1389en_US
dc.identifier.issn0256-7040en_US
dc.identifier.issn1433-0350en_US
dc.identifier.issue12en_US
dc.identifier.pmid18828024en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1385en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00381-008-0716-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22501
dc.identifier.volume24en_US
dc.identifier.wosWOS:000260835700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofCHILDS NERVOUS SYSTEMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildrenen_US
dc.subjectLow-grade gliomaen_US
dc.subjectMalignant transformationen_US
dc.subjectObservation without surgeryen_US
dc.subjectSurgical resectionen_US
dc.titleMalignant glioblastomatous transformation of a low-grade glioma in a childen_US
dc.typeArticleen_US

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