Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorGüler, Gökalp Özmen
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorPicot, Carene Marie Nancy
dc.contributor.authorMahomoodally, ‪Mohamad Fawzi
dc.date.accessioned2020-03-26T19:05:55Z
dc.date.available2020-03-26T19:05:55Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (alpha-amylase and alpha-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase). The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays. The total antioxidant capacity (TAC), beta-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH center dot), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts. The half-maximal inhibitory concentrations (IC50) of the extracts on cholinesterase, tyrosinase, and alpha-amylase were significantly higher than the references, galantamine, kojic acid, and acarbose, respectively. The half-maximal effective concentrations (EC50) of the extracts on TAC, CUPRAC, and FRAP were significantly higher than trolox. The phenol and flavonoid contents of the plant extracts were in the range 20.90 +/- 0.190-83.25 +/- 0.914mg gallic acid equivalent/g extract and 1.45 +/- 0.200-39.71 +/- 0.092mg rutin equivalent/g extract, respectively. The plants were found to possess moderate antioxidant capacities and interesting inhibitory action against key enzymes.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z892]en_US
dc.description.sponsorshipThis research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (Project no. 113Z892).en_US
dc.identifier.doi10.1155/2015/410675en_US
dc.identifier.issn1687-6334en_US
dc.identifier.issn1687-6342en_US
dc.identifier.pmid26798334en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://dx.doi.org/10.1155/2015/410675
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32110
dc.identifier.wosWOS:000367615700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofADVANCES IN PHARMACOLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEnzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkeyen_US
dc.typeArticleen_US

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