Relationship between primary tumour F-18-FDG uptake and immunohistochemical and clinical prognostic parameters in breast carcinoma

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dc.contributor.authorGedik, G. K.
dc.contributor.authorYilmaz, F.
dc.contributor.authorSari, O.
dc.date.accessioned2020-03-26T19:42:29Z
dc.date.available2020-03-26T19:42:29Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The objective of this study was to investigate the relationship between level of F-18-fluorodeoxyglucose (F-18-FDG) accumulation in primary breast tumour assessed by positron emission tomography/computed tomography (PET/CT) and histopathological and clinical prognostic factors. Material and methods: A retrospective analysis was performed using the medical records of 58 female patients (age range: 31-86 years, mean age: 56) with biopsy of proven breast carcinoma, and who had undergone 18F-FDG PET/CT examination before chemotherapy/surgery. The 18F-FDG uptake of breast tumours was calculated as tumour to background ratio (TBR); which was compared with histopathological and clinical prognostic parameters. Results: The histology of the breast tumour in the 58 patients was ductal type in 52 (90%), lobular in 4 (7%), and mucinous in 2 (3%). Tumour size was <= 2 cm in 31 (53%) patients, and > 2 cm in 27 (47%). The levels of TBRs were not significantly different between the patients groups with tumours of 2 cm or less and greater than 2 cm (P= 0.131). No significant difference between levels of TBR was observed neither with regards to axillary lymph node involvement (P= 0.065) nor in terms of distant metastases (p = 0.123). No statistically significant difference was found in levels of TBRs between patients with c-erbB-2 receptor positive and negative ones (P= 0.107). Progesterone receptor (PR) expression was observed in 33 patients (57%), and 25 patients (43%) were PR negative. As regards progesterone receptor status, a statistically significant difference was observed in mean TBR levels between patients with and without progesterone receptor expression (P=0.020). Oestrogen receptor expression was positive in 41 (71%) patients, and negative in 17 (29%) patients. The difference in the levels of TBRs between patients with and without oestrogen receptor expression was at the level of significancy (P= 0.050). Conclusions: It is concluded that F-18-FDG uptake correlates with progesterone negativity of the tumour. However, a significant association with clinical prognostic parameters and level of 18F-FDG uptake levels could not be demonstrated. (C) 2016 Elsevier Espana, S.L.U. y SEMNIM. All rights reserved.en_US
dc.identifier.doi10.1016/j.remn.2016.09.006en_US
dc.identifier.endpage157en_US
dc.identifier.issn2253-654Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid27856207en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.remn.2016.09.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35432
dc.identifier.volume36en_US
dc.identifier.wosWOS:000400803400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER DOYMA SLen_US
dc.relation.ispartofREVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULARen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBreast carcinomaen_US
dc.subjectPrognosisen_US
dc.subjectTumour to background ratioen_US
dc.subjectF-18-FDGen_US
dc.titleRelationship between primary tumour F-18-FDG uptake and immunohistochemical and clinical prognostic parameters in breast carcinomaen_US
dc.typeArticleen_US

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