Anaphylaxis in Turkish children: a multi-centre, retrospective, case study

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dc.contributor.authorOrhan, F.
dc.contributor.authorCanitez, Y.
dc.contributor.authorBakirtas, A.
dc.contributor.authorYilmaz, O.
dc.contributor.authorBoz, A. B.
dc.contributor.authorCan, D.
dc.contributor.authorKuyucu, S.
dc.date.accessioned2020-03-26T18:13:46Z
dc.date.available2020-03-26T18:13:46Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground Anaphylaxis is a serious and potentially lethal systemic reaction affecting more than one organ or system. Objective We aimed to describe the demographic characteristics, clinical features, causes, settings, and administered therapy in Turkish children. Methods This retrospective, case note study included all children referred to the outpatient clinics of the Pediatric Allergy Departments of the participating study centres from 1 July 1999 to 30 June 2009 for investigation of anaphylaxis or who were seen by us at the moment of the reaction during the same period and who met the clinical criteria of anaphylaxis. Results Two hundred and twenty-four cases of anaphylaxis were reported in 137 children (88 boys, P = 0.0001). The mean +/- SD age at the referral was 7.7 +/- 4.2 years (range: 4 months-17 years). Ninety-eight episodes (43.8%) occurred at home. The symptoms were cutaneous in 222 (99.1%) episodes, respiratory in 217 (96.9%), neuro-psychiatric in 118 (52.7%), cardiovascular in 92 (41.1%), and gastrointestinal in 88 (39.3%). Biphasic reaction was reported in seven episodes (3.1%, 95% CI: 1.5-6.3). Death occurred in one case (0.4%, 95% CI: 0.08-2.4). Treatment was available in 158 episodes (70.5%). Of them, 148 (93.7%) received antihistamines, 132 (83.5%) corticosteroids, 51 (32.3%) epinephrine, and 17 (10.8%) beta-2-mimetics. The causative agents were foods in 86 (38.4%) episodes, hymenoptera venom in 84 (37.5%), drugs and medications in 47 (21.0%), and latex in 5 (2.2%). In two episodes (0.9%), the causative agent was unidentified. Allergy to the trigger was known prior to anaphylaxis in 116 (51.8%) episodes. An epinephrine autoinjector had been prescribed for 70 children (51.1%). Conclusions and Clinical Relevance Anaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first-line treatment of anaphylaxis, was administered in only a third of the children.en_US
dc.identifier.doi10.1111/j.1365-2222.2011.03859.xen_US
dc.identifier.endpage1776en_US
dc.identifier.issn0954-7894en_US
dc.identifier.issn1365-2222en_US
dc.identifier.issue12en_US
dc.identifier.pmid22092675en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1767en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1365-2222.2011.03859.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26139
dc.identifier.volume41en_US
dc.identifier.wosWOS:000297283800013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL ALLERGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectanaphylaxisen_US
dc.subjectchildrenen_US
dc.subjectepidemiologyen_US
dc.titleAnaphylaxis in Turkish children: a multi-centre, retrospective, case studyen_US
dc.typeArticleen_US

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