Postconditioning ozone alleviates ischemia-reperfusion injury and enhances flap endurance in rats

Basit Öğe Kaydı
dc.contributor.authorElsürer, Çağdaş
dc.contributor.authorÖnal, Merih
dc.contributor.authorSelimoğlu, Nebil
dc.contributor.authorErdur, Ömer
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorErdoğan, Ender
dc.contributor.authorKal, Öznur
dc.contributor.authorÇelik, Jale Bengi
dc.contributor.authorÖnal, Özkan
dc.date.accessioned2020-03-26T20:20:54Z
dc.date.available2020-03-26T20:20:54Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractMuscle-flap transferring is a routine approach utilized in reconstructive operations; however, flap morbidity is often a source of post-operative difficulty. Ischemia-Reperfusion Injury (IRI) is an important contributor to the viability of flaps after transferring. The goal of this research was for assess the probable useful impacts of ozone on flap survival in a rat muscle-flap design. Materials and Methods: We examined the effects of postconditioning ozone administration on viability of pedicled composite flaps. Twenty-eight Wistar rats were randomized into four groups: sham-operated (S), ischemia-reperfusion (IR), sham-operated + ozone (O), IR + ozone (IR + O), respectively. The animals were sacrificed on the eighth day. In a general histological evaluation, flap tissues were examined with a light microscope, and apoptotic cells were counted. The Apoptotic Index (AI) was then calculated. Flap-tissue samples were sent for analyses of malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and protein carbonyl (PCO), and blood samples were sent for analyses of Total Oxidant Score (TOS), and Total Antioxidant Capacity (TAC). Data were evaluated statistically using the Kruskal–Wallis test. Results: The histomorphometric score was remarkably greater in O (p =.002). The AI was greater in IR (p =.002). The antioxidant parameters values as regards SOD, GSH-Px, CAT, and TAC were found to be greater in O (p <.005). The oxidant parameters values as regards MDA, PCO, TOS were found to be greater in IR (p <.005). Discussion: The current research indicates that ozone application can attenuate the muscle-flap injury brought about by IR through triggering the increase of the antioxidant capacity.en_US
dc.identifier.citationElsürer, Ç., Önal, M., Selimoğlu, N., Erdur, Ö., Yılmaz, M., Erdoğan, E., Kal, Ö., Çelik, J.B., Önal, Ö. (2020). Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats. Journal of Investigative Surgery, 33,(1), 15-24.
dc.identifier.doi10.1080/08941939.2018.1473901en_US
dc.identifier.endpage24en_US
dc.identifier.issn0894-1939en_US
dc.identifier.issue1en_US
dc.identifier.pmid30339503en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://dx.doi.org/10.1080/08941939.2018.1473901
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38694
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorElsürer, Çağdaş
dc.institutionauthorÖnal, Merih
dc.institutionauthorErdur, Ömer
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectantioxidanten_US
dc.subjectapoptosisen_US
dc.subjectischemia reperfusion injuryen_US
dc.subjectozoneen_US
dc.subjectsurgical flapsen_US
dc.titlePostconditioning ozone alleviates ischemia-reperfusion injury and enhances flap endurance in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
MERİH ÖNAL.pdf
Boyut:
2.08 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Kulak, Burun ve Boğaz Hastalıkları/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu