Prolactin levels in manganese-exposed male welders

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dc.contributor.authorTutkun, Engin
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorYılmaz, Ömer Hınç
dc.contributor.authorGündüzöz, Meside
dc.contributor.authorGıynaş, Nilgün
dc.contributor.authorBal, Ceylan Demir
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2020-03-26T18:58:26Z
dc.date.available2020-03-26T18:58:26Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose Early studies on manganese (Mn) exposure have demonstrated that this transition metal affects dopamine neurotransmission. Dopamine serves as a tonic inhibitor of prolactin release in the anterior hypophysis. Our aim was to determine the relation between serum prolactin levels and manganese-exposure. Methods Whole blood was collected from 95 nonexposed control subjects and 179 manganese-exposed male welders. Whole blood manganese was analyzed by Inductively Coupled Plasma-Mass Spectrometer on Agilent 7700 (Agilent Technologies, USA). Serum prolactin levels (PRL), aspartate transaminase (AST), alanine transaminase (ALT), urea, creatinine, soduim (Na), potassium (K) were analyzed by immunological and spectrophotometric methods on Roche E170 Modular System (Roche Diagnostics, Mannheim, Germany). Results The mean ages for control and manganeseexposed group were 40.5 +/- 7.8 and 39.5 +/- 8.7, respectively (p = 0.258). The mean working period (years) for control and manganese-exposed group were 17.4 +/- 9.8 and 18.2 +/- 7.7 years, respectively (p = 0.581). Serum AST and potassium levels were significantly higher in control group than manganese-exposed group (p = 0.002 and p = 0.048, respectively) and body-mass index (BMI) was significantly lower in control group than manganeseexposed group (p = 0.033). There was a significantly positive correlation between whole blood manganese levels and serum prolactin (r = 0.860, p < 0.001). Serum ALT levels were positively correlated with serum AST, urea and sodium (r = 0.315, p < 0.001; r = 0.121, p = 0.046; r = 0.130, p = 0.031). Conclusions Serum prolactin level is a diagnostic marker for determining the effect of manganese-exposure.en_US
dc.identifier.doi10.1007/s11102-013-0545-6en_US
dc.identifier.endpage568en_US
dc.identifier.issn1386-341Xen_US
dc.identifier.issn1573-7403en_US
dc.identifier.issue6en_US
dc.identifier.pmid24337778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage564en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11102-013-0545-6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31091
dc.identifier.volume17en_US
dc.identifier.wosWOS:000346963100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPITUITARYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectProlactinen_US
dc.subjectManganese toxicityen_US
dc.subjectBiomarkeren_US
dc.subjectExposureen_US
dc.titleProlactin levels in manganese-exposed male weldersen_US
dc.typeArticleen_US

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