The Investigation of Gingival Iron Accumulation in Thalassemia Major Patients

dc.contributor.authorCaliskan, Umran
dc.contributor.authorTonguc, Mine Ozturk
dc.contributor.authorCiris, Metin
dc.contributor.authorBalta, Nihal
dc.contributor.authorKirzioglu, Fatma Yesim
dc.contributor.authorCaglayan, Gurhan
dc.contributor.authorCanatan, Duran
dc.date.accessioned2020-03-26T18:17:01Z
dc.date.available2020-03-26T18:17:01Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Thalassemia major (TM) is an autosomal-recessive genetic blood disorder. Regular blood transfusions to improve chronic anemia caused by ineffective erythropoiesis and hemolysis lead to iron overload in many organs in TM patients. The aim of this study was to investigate the periodontal status and the iron accumulation in gingival tissues of TM patients and assess whether iron deposition in gingival biopsies could be an alternative method for the diagnosis of body iron overload in TM patients. Materials and Methods: This study was conducted on 22 TM patients and 20 healthy matched controls. Plaque index, gingival index, and probing pocket depth were measured and gingival biopsies were obtained in all subjects. Venous blood samplings and liver biopsies were carried out only in patients with thalassemia. Gingiva and liver tissue samples were evaluated histopathologically for inflammation, iron accumulation, and fibrosis. Results: There was no difference between the groups regarding periodontal health, and all patients had mild gingivitis. Gingival iron accumulation was observed only in the TM group. The iron accumulation was detected in the liver of all the patients with thalassemia. The gingival iron accumulation was correlated with neither serum ferritin levels nor hepatic iron accumulations. Conclusions: The periodontal tissues are affected by iron accumulation as well as hepatic, cardiac, and endocrine tissues in TM patients. Further studies investigating the usage of the gingival biopsy for prediagnosis of body iron overload in TM patients are needed.en_US
dc.description.sponsorshipSuleyman Demirel University, Unit of Scientific ResearchSuleyman Demirel University [657]en_US
dc.description.sponsorshipThis study was supported by a grant from Suleyman Demirel University, Unit of Scientific Research Projects (Grant number 657).en_US
dc.identifier.doi10.1097/MPH.0b013e3182025058en_US
dc.identifier.endpage102en_US
dc.identifier.issn1077-4114en_US
dc.identifier.issn1536-3678en_US
dc.identifier.issue2en_US
dc.identifier.pmid21285897en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MPH.0b013e3182025058
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26964
dc.identifier.volume33en_US
dc.identifier.wosWOS:000287648800017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectthalassemiaen_US
dc.subjectiron overloaden_US
dc.subjectgingivaen_US
dc.titleThe Investigation of Gingival Iron Accumulation in Thalassemia Major Patientsen_US
dc.typeArticleen_US

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