Characterization of dental pulp defect and repair in a canine model

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dc.contributor.authorYildirim, Sibel
dc.contributor.authorCan, Alp
dc.contributor.authorArican, Mustafa
dc.contributor.authorEmbree, Mildred C.
dc.contributor.authorMao, Jeremy J.
dc.date.accessioned2020-03-26T18:13:54Z
dc.date.available2020-03-26T18:13:54Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To explore a relationship between the size of pulp chamber perforation and reparative dentin formation in a canine model. Methods: Pulp defects were created in the pulp chambers of maxillary and mandibular premolars (N=64) in 17 healthy mongrel dogs in three different sizes (diameter/depth: 1/1, 2/1, and 2/2 mm(3)) with sterile round burs under general anesthesia. The perforations were immediately capped with hard-setting calcium hydroxide (CH) in the control group or sealed with Teflon membrane (TM) in the experimental group, followed by restoration with reinforced zinc oxide eugenol cement in vivo. Seven and 30 days after pulp chamber perforation and restoration all treated and control premolars were extracted and prepared for histomorphometric and statistical analyses. Results: Reparative dentin formation was more pronounced for defect sizes up to 2/1 mm(3) when treated with CH, and completely bridged the surgically created dentin defects only after 30 days. However, reparative dentin upon CH treatment failed to completely bridge pulp chamber exposure for 2/2 defects. By contrast, TM treatment only yielded mild reparative dentin bridging for defects up to 1/1, but not for either 2/1 or 2/2 defects at 30 days. Inflammatory responses of the exposed dental pulp tissue were more robust with the TM group than with the CH group. Thus, dental pulp tissue possesses a capacity for spontaneous repair by the formation of reparative dentin in this preclinical model, but only up to a defect size of similar to 2 mm in diameter and 1 mm in depth. All observations are based on 30 days post-treatment in the canine model. These findings may serve as baseline for regenerative endodontic studies (Am J Dent 2011;24:331-335).en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [BAP-2002/191]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [RC2DE020767]en_US
dc.description.sponsorshipThe authors declared no conflict of interest. Scientific Research Projects of Selcuk University Grant supported this study, BAP-2002/191 to Dr. Yildirim and NIH grant RC2DE020767 to Dr. Mao.en_US
dc.identifier.endpage335en_US
dc.identifier.issn0894-8275en_US
dc.identifier.issue6en_US
dc.identifier.pmid22263328en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26218
dc.identifier.volume24en_US
dc.identifier.wosWOS:000298446300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMOSHER & LINDER, INCen_US
dc.relation.ispartofAMERICAN JOURNAL OF DENTISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleCharacterization of dental pulp defect and repair in a canine modelen_US
dc.typeArticleen_US

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