An unusual association between familial Mediterranean fever and IgM nephropathy

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dc.contributor.authorPeru, Harun
dc.contributor.authorElmaci, Ahmet Midhat
dc.contributor.authorAkin, Fatih
dc.contributor.authorAkcoren, Zuhal
dc.contributor.authorOrhan, Diclehan
dc.date.accessioned2020-03-26T17:26:24Z
dc.date.available2020-03-26T17:26:24Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To report a case with the diagnosis of IgM nephropathy and familial Mediterranean fever (FMF). Clinical Presentation and Intervention: A 9-year-old boy was admitted to our hospital with recurrent abdominal pain since the age of 4 years. Laboratory investigations revealed a sedimentation rate of 88 mm/h, C-reactive protein: 83.2 mg/l (0-10 mg/l), white blood cell count: 12,700/mm(3), fibrinogen: 622 mg/dl (200-400 mg/dl) and serum amyloid A: 186 mg/l (0-5.8 mg/l). Urinalysis revealed +2 proteinuria. A 24-hour urinary protein excretion was 12 mg/m(2)/h. M694V homozygous mutation was identified in exon 10. Percutaneous renal biopsy showed mesangial cell proliferation and increased mesangial matrix in the glomeruli, without amyloid accumulation. Immunofluorescence study showed IgM (+1) and C1q (+1) deposits. Treatment with 1 mg/day colchicine was started. Six weeks later, proteinuria had disappeared and the patient was asymptomatic. Conclusion: This case illustrates the unusual association of FMF with non-amyloid glomerulopathy. Glomerular diseases such as IgM nephropathy may be seen as a manifestation of FMF. Copyright (C) 2008 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000117803en_US
dc.identifier.endpage257en_US
dc.identifier.issn1011-7571en_US
dc.identifier.issue3en_US
dc.identifier.pmid18408398en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000117803
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22204
dc.identifier.volume17en_US
dc.identifier.wosWOS:000254894400015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofMEDICAL PRINCIPLES AND PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfamilial Mediterranean feveren_US
dc.subjectglomerulonephritisen_US
dc.subjectIgM nephropathyen_US
dc.titleAn unusual association between familial Mediterranean fever and IgM nephropathyen_US
dc.typeArticleen_US

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