Stevens-Johnson syndrome due to concomitant use of lamotrigine and valproic acid

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dc.contributor.authorKocak, Sedat
dc.contributor.authorGirisgin, Sadik A.
dc.contributor.authorGul, Mehmet
dc.contributor.authorCander, Basar
dc.contributor.authorKaya, Halil
dc.contributor.authorKaya, Esengul
dc.date.accessioned2020-03-26T17:18:16Z
dc.date.available2020-03-26T17:18:16Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description3rd Mediterranean Emergency Medicine Congress -- SEP 01-05, 2005 -- Nice, FRANCEen_US
dc.description.abstractStevens-Johnson syndrome (SJS) is a rare but life-threatening acute mucocutaneous hypersensitivity reaction, usually related to drugs. Severe cutaneous adverse effects such as SJS and toxic epidermal necrolysis can arise during treatment with antiepileptic drugs (AEDs). A 23-year-old female patient with idiopathic epilepsy was referred to the emergency service with fever, oral and genital mucosal lesions, generalized rash, and weakness. She had been taking carbamazepine, valproic acid, and lamotrigine until 1 week prior to referral. Following consultations with a range of clinicians, the patient was diagnosed with SJS related to lamotrigine on the basis of her history and physical findings, and on consideration of current consensus definitions of this condition. The patient was followed up and treated in the emergency intensive care unit with intravenous fluids, antibacterial therapy, and methylprednisolone. After 18 days, the patient was considered to have made a sufficient recovery and was discharged. Patients who undergo therapy with AEDs, particularly new users of these agents, should be informed of and monitored for possible systemic and cutaneous adverse effects of AEDs. Polytherapy should be avoided for as long as possible as this increases the frequency of adverse effects, and treatment should be discontinued if any rash appears.en_US
dc.identifier.doi10.2165/00128071-200708020-00007en_US
dc.identifier.endpage111en_US
dc.identifier.issn1175-0561en_US
dc.identifier.issn1179-1888en_US
dc.identifier.issue2en_US
dc.identifier.pmid17428116en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://dx.doi.org/10.2165/00128071-200708020-00007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21622
dc.identifier.volume8en_US
dc.identifier.wosWOS:000246242100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherADIS INT LTDen_US
dc.relation.ispartofAMERICAN JOURNAL OF CLINICAL DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleStevens-Johnson syndrome due to concomitant use of lamotrigine and valproic aciden_US
dc.typeArticleen_US

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