In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries

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dc.contributor.authorArun, O.
dc.contributor.authorTaylan, S. B.
dc.contributor.authorDuman, I
dc.contributor.authorOc, B.
dc.contributor.authorYilmaz, S. A.
dc.contributor.authorTekin, A.
dc.contributor.authorCelik, C.
dc.contributor.authorBariskaner H.
dc.contributor.authorCelik J. B.
dc.date.accessioned2020-03-26T20:14:41Z
dc.date.available2020-03-26T20:14:41Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: We aimed to investigate the vasoactive effects of dexmedetomidine on isolated human umbilical arteries and possible mechanisms involved. METHODS: Human umbilical artery strips were suspended in Krebs-Henseleit solution and dose-response curves were obtained for cumulative dexmedetomidine before and after incubation with different agents; propranolol, atropine, yohimbine, prazosin, indomethacin, verapamil. Effects of calcium on cumulative dexmedetomidine-induced contractions were also studied. RESULTS: Cumulative dexmedetomidine resulted in dose dependent contraction responses. Incubation with propranolol (Emax: 93.3 +/- 3.26 %), atropine (Emax: 92.0 +/- 6.54 %), or indomethacin (Emax: 94.25 +/- 2.62 %), did not attenuate dexmedetomidine-elicited contractions (p > 0.05). There were significant decreases in the contraction responses of cumulative dexmedetomidine with yohimbine (Emax: 12.1 +/- 11.9 %), prazosin (Emax: 28.8 +/- 4.6 %) and verapamil (Emax: 11.2 +/- 13.6 %) (p < 0.05). In Ca+2 free medium contraction responses to cumulative dexmedetomidine was insignificant (Emax: 5.20 +/- 3.42 %). Addition of cumulative calcium to the Ca+2 free medium resulted in concentration dependent increase in contractions (Emax: 64.83 +/- 37.7 %) (p < 0.05). CONCLUSION: Dexmedetomidine induces vasoconstriction in endothelial-free umbilical arteries via both, alpha(1)- and alpha(2)-adrenergic receptors and also extracellular Ca+2 concentrations play a major role. beta-adrenergic receptors, muscarinic cholinergic receptors, and inhibition of cyclooxygenase enzyme are not involved in this vasoconstriction (Fig. 3, Ref. 36). Text in PDF www.elis.sk.en_US
dc.identifier.citationArun, O., Taylan, S. B., Duman, I., Oc, B., Yilmaz, S. A., Tekin, A., Celik, C.., Bariskaner H.., Çelik, J. B. (2019). In Vitro Vasoactive Effects Of Dexmedetomidine On İsolated Human Umbilical Arteries. Bratislavske Lekarske Listy, 120,(1), 40-45.
dc.identifier.doi10.4149/BLL_2019_006en_US
dc.identifier.endpage45en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue1en_US
dc.identifier.pmid30685991en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2019_006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37920
dc.identifier.volume120en_US
dc.identifier.wosWOS:000457596700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArun, O.
dc.institutionauthorTaylan, S. B.
dc.institutionauthorOc, B.
dc.institutionauthorYilmaz, S. A.
dc.institutionauthorTekin, A.
dc.institutionauthorCelik, C.
dc.institutionauthorBariskaner H.
dc.institutionauthorCelik J. B.
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalpha adrenergic receptorsen_US
dc.subjectdexmedetomidineen_US
dc.subjectin vitroen_US
dc.subjectumbilical corden_US
dc.subjectvascular smooth muscleen_US
dc.titleIn vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteriesen_US
dc.typeArticleen_US

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