Effects of Nimodipine and Magnesium Sulfate on Endogenous Antioxidant Levels in Brain Tissue After Experimental Head Trauma

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dc.contributor.authorÜstün, Mehmet Erkan
dc.contributor.authorDuman, Ateş
dc.contributor.authorÖğün, Cemile Öztin
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorAk, Ahmet
dc.date.accessioned2020-03-26T16:37:07Z
dc.date.available2020-03-26T16:37:07Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo examine the effects of calcium antagonists nimodipine and magnesium sulfate (MgSO4) on tissue endogenous antioxidant levels, the authors studied superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in rabbit brain 1 hour after experimental head trauma. Forty New Zealand rabbits were anesthetized and randomly divided into four groups. Group 1 (n = 10) was the sham operated group. Group 2 (n = 10), the control group, received head trauma and no treatment. Group 3 (n = 10) received head trauma and intravenous (IV) 2 mu gr/kg nimodipine. Group 4 (n = 10) received head trauma and IV 100 mg/kg MgSO4. Head trauma was delivered by performing a craniectomy over the right hemisphere and dropping a weight of 20 g from a height of 40 cm. In the right (traumatized) hemisphere, SOD and GPx decreased by 57.60% +/- 9.60% and 72.93% +/- 5.51% respectively from sham values. Magnesium sulfate, but not nimodipine, reduced the magnitude of decrease of SOD and GPx to 19.43% +/- 7.15% and 39.01% +/- 7.92% respectively from sham values. In the left (nontraumatized) hemisphere, MgSO4 increased SOD to 42.43% +/- 24.76% above sham values. The authors conclude that MgSO4 treatment inhibited the decrease in SOD and GPx levels in experimental brain injury.en_US
dc.identifier.citationÜstün, M. E., Duman, A., Öğün, C. Ö., Vatansev, H., Ak, A., (2001). Effects of Nimodipine and Magnesium Sulfate on Endogenous Antioxidant Levels in Brain Tissue After Experimental Head Trauma. Journal of Neurosurgical Anesthesiology, 13(3), 227-232.
dc.identifier.endpage232en_US
dc.identifier.issn0898-4921en_US
dc.identifier.issue3en_US
dc.identifier.pmid11426097en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17540
dc.identifier.volume13en_US
dc.identifier.wosWOS:000169475400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜstün, Mehmet Erkan
dc.institutionauthorDuman, Ateş
dc.institutionauthorÖğün, Cemile Öztin
dc.institutionauthorVatansev, Hüsamettin
dc.institutionauthorAk, Ahmet
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJournal of Neurosurgical Anesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectHead Traumaen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectNimodipine-Rabbiten_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleEffects of Nimodipine and Magnesium Sulfate on Endogenous Antioxidant Levels in Brain Tissue After Experimental Head Traumaen_US
dc.typeArticleen_US

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