Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males?

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dc.contributor.authorBilgic, Ozlem
dc.contributor.authorAltinyazar, Hilmi Cevdet
dc.contributor.authorEryilmaz, Dilek
dc.contributor.authorTugrul, Zehra Ayca
dc.date.accessioned2020-03-26T19:23:07Z
dc.date.available2020-03-26T19:23:07Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Although the pathogenesis of androgenetic alopecia is not completely understood, the roles of genetic susceptibility and androgens are well-known. A lower ratio of the second digit (index finger = 2D) to the fourth digit (ring finger = 4D) length has been hypothesized to reflect prenatal androgen exposure and/or higher sensitivity to androgens. OBJECTIVES: To determine the relationship between the second to fourth digit length ratio and androgenetic alopecia. METHODS: Finger length measurements were made by a digital vernier calliper. Androgenetic alopecia severity was assessed using the Hamilton-Norwood scale. Subjects with an androgenetic alopecia score of grade III or more were included in the study. RESULTS: A total of 189 males with androgenetic alopecia and 171 healthy controls were enrolled in the study. The age range of participants was 19-65 years. The 2D:4D ratios in patients with androgenetic alopecia were significantly lower than those of healthy controls for the right hand; however, no significant difference was found for the left hand. Average 2D:4D ratios in androgenetic alopecia patients were also lower than in controls. No significant relationship was observed between androgenetic alopecia severity and 2D:4D ratios. CONCLUSION: Our data support the anatomical evidence of in utero androgen exposure and/or an individual's sensitivity to androgens in patients with androgenetic alopecia. Furthermore, the right hand 2D:4D ratio might be an indicator of androgenetic alopecia development.en_US
dc.identifier.doi10.1590/abd1806-4841.20164622en_US
dc.identifier.endpage159en_US
dc.identifier.issn0365-0596en_US
dc.identifier.issn1806-4841en_US
dc.identifier.issue2en_US
dc.identifier.pmid27192513en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage156en_US
dc.identifier.urihttps://dx.doi.org/10.1590/abd1806-4841.20164622
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33275
dc.identifier.volume91en_US
dc.identifier.wosWOS:000376993400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSOC BRASILEIRA DERMATOLOGIAen_US
dc.relation.ispartofANAIS BRASILEIROS DE DERMATOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlopeciaen_US
dc.subjectAndrogensen_US
dc.subjectFingersen_US
dc.subjectHyperandrogenismen_US
dc.subjectReceptors, androgenen_US
dc.titleAre 2D:4D finger-length ratios an indicator of androgenetic alopecia in males?en_US
dc.typeArticleen_US

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