Cognitive function in chronic obstructive pulmonary disease: Relationship to global initiative for chronic obstructive lung disease 2011 categories

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dc.contributor.authorTulek, Baykal
dc.contributor.authorAtalay, Nart Bedin
dc.contributor.authorYildirim, Gulfem
dc.contributor.authorKanat, Fikret
dc.contributor.authorSuerdem, Mecit
dc.date.accessioned2020-03-26T18:49:45Z
dc.date.available2020-03-26T18:49:45Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective: Recently, comorbidities such as impaired cognitive function have been attracting more focus when considering the management of chronic obstructive pulmonary disease (COPD). Here we investigated the relationship between cognitive function and the categories given in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in 2011. Specifically, after controlling for non-COPD covariates, we assessed the clinical features that may be predictive of cognitive impairment in patients with COPD. Methods: We recruited 119 stable patients with mild to very severe COPD. We administered a broad array of standardized neuropsychological tests that assessed cognitive functions in the domains of attention, memory, psychomotor coordination and language. Results: Cognitive scores were significantly different between patients falling within GOLD 2011 categories. Scores were lower in patients with high future risk compared with low future risk. In parallel, there were significant differences in cognitive function between COPD patient subgroups when patients were grouped according to the forced expiratory volume in 1 s, exacerbation history and C-reactive protein levels. After controlling for non-COPD predictors, only exacerbation history remained a significant predictor of cognitive scores. Conclusions: The number of exacerbation events in a year may be used as a predictor of cognitive impairment in patients with COPD.en_US
dc.identifier.doi10.1111/resp.12333en_US
dc.identifier.endpage880en_US
dc.identifier.issn1323-7799en_US
dc.identifier.issn1440-1843en_US
dc.identifier.issue6en_US
dc.identifier.pmid24935516en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage873en_US
dc.identifier.urihttps://dx.doi.org/10.1111/resp.12333
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30677
dc.identifier.volume19en_US
dc.identifier.wosWOS:000340659800015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofRESPIROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcognitive functionen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectexacerbationen_US
dc.subjectMini Mental State Examinationen_US
dc.titleCognitive function in chronic obstructive pulmonary disease: Relationship to global initiative for chronic obstructive lung disease 2011 categoriesen_US
dc.typeArticleen_US

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