Biocompatible thermoresponsive PEGMA nanoparticles crosslinked with cleavable disulfide-based crosslinker for dual drug release

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dc.contributor.authorUlasan, Mehmet
dc.contributor.authorYavuz, Emine
dc.contributor.authorBagriacik, Emin Umit
dc.contributor.authorCengeloglu, Yunus
dc.contributor.authorYavuz, Mustafa Selman
dc.date.accessioned2020-03-26T19:01:07Z
dc.date.available2020-03-26T19:01:07Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSmart materials have been attracting much attention because of their stimuli responsive nature. We have synthesized biocompatible thermoresponsive crosslinked poly(ethylene glycol) methyl ether methacrylate (PEGMA)-co-vinyl pyrrolidone nanoparticles (PEGMA NPs) using disulfide-based crosslinker by surfactant-free emulsion polymerization method. Particle characterization studies were carried out by dynamic light scattering, and scanning electron microscopy. Polymerization kinetics, effect of crosslinker and initiator concentrations on both average hydrodynamic diameter and polydispersity index were investigated. Hydrodynamic diameters of thermoresponsive PEGMA NPs were decreased from 210 nm to 90 nm upon heating over the lowest critical solution temperature (LCST). Disulfide crosslinked PEGMA NPs were demonstrated as a dual delivery system. Rhodamine B, a model of small-sized drug molecule, and poly(ethylene glycol) (PEG)-alizarin yellow, a model of large drug molecule, were loaded into PEGMA NPs where LCST of these NPs was tuned to 37 degrees C, the body temperature. The rhodamine B was released from PEGMA NPs upon heating to 39 degrees C. Then, PEG-alizarin content was released by subsequent degradation of nanoparticles using dithiothreitol (DTT), which reduces disulfide bonds to thiols. Furthermore, cytotoxicity studies of PEGMA NPs were carried out in 3T3 cells, which resulted in no toxic effect on the cells. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 243-251, 2015.en_US
dc.description.sponsorshipMarie Curie International ReintegrationEuropean Union (EU) [PIRG-GA-2009-256514]; Selcuk University Scientific Research FundSelcuk University [12201077]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112M096, COST TD1004]en_US
dc.description.sponsorshipContract grant sponsor: Marie Curie International Reintegration; contract grant number: PIRG-GA-2009-256514; Contract grant sponsor: Selcuk University Scientific Research Fund; contract grant number: S.U. BAP no: 12201077; Contract grant sponsor: The Scientific and Technological Research Council of Turkey; contract grant number: 112M096, COST TD1004en_US
dc.identifier.doi10.1002/jbm.a.35146en_US
dc.identifier.endpage251en_US
dc.identifier.issn1549-3296en_US
dc.identifier.issn1552-4965en_US
dc.identifier.issue1en_US
dc.identifier.pmid24616340en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jbm.a.35146
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31891
dc.identifier.volume103en_US
dc.identifier.wosWOS:000345572100027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART Aen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectstimuli-responsive nanoparticlesen_US
dc.subjectpoly ethylene glycol methyl ether methacrylateen_US
dc.subjectdrug deliveryen_US
dc.subjectdisulfide-based crosslinkeren_US
dc.subjectsurfactant-free emulsion polymerizationen_US
dc.titleBiocompatible thermoresponsive PEGMA nanoparticles crosslinked with cleavable disulfide-based crosslinker for dual drug releaseen_US
dc.typeArticleen_US

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