Sildenafil Citrate Does Not Affect Qt Intervals and Qt Dispersion: an Important Observation for Drug Safety

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dc.contributor.authorAlpaslan, Mete
dc.contributor.authorOnrat, Ersel
dc.contributor.authorŞamlı, Murat
dc.contributor.authorDinçel, Çetin
dc.date.accessioned2020-03-26T16:46:04Z
dc.date.available2020-03-26T16:46:04Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Sildenafil is an effective and widely used therapeutic agent for erectile dysfunction. Deaths have been reported due to sildenafil use and most of them are attributed to concurrent use of nitrates. However, the effects of sildenafil on QT intervals, QT dispersion, and the possible risk of ventricular arrhythmia have not been studied before. Our aim in this study was to evaluate the effect of sildenafil citrate on QT intervals and QT dispersion. Methods: Thirty-six patients with erectile dysfunction were included in this study. Twenty-one patients had coronary artery disease whereas 12 of them also had accompanying diabetes mellitus. Standard 12-lead electrocardiograms (ECG) were recorded three times: before, and at the first and fourth hours of 50 mg sildenafil citrate ingestion. All QT parameters were corrected for heart rate. Results: Mean age of the patients was 54 12 years. The mean heart rate did not differ significantly between the three ECG examinations. The corrected and uncorrected maximum and minimum QT intervals were not significantly different between the three ECG examinations. The QT dispersion and corrected QT dispersion before and 1 hour and 4 hours after sildenafil ingestion were 31 9 ms, 36 +/- 10 ms; 32 +/- 11 ms, 37 +/- 14 ms; 27 +/- 8 ms, 32 +/- 9 ms, respectively (P > 0.05). Conclusions: Sildenafil does not prolong QT intervals or increase QT dispersion in patients with erectile dysfunction. Our results suggest that the risk of ventricular arrhythmia does not increase with ingestion of 50 mg sildenafil.en_US
dc.identifier.citationAlpaslan, M., Onrat, E., Şamlı, M., Dinçel, Ç., (2003). Sildenafil Citrate Does Not Affect Qt Intervals and Qt Dispersion: an Important Observation for Drug Safety. Annals of Noninvasive Electrocardiology, 8(1), 14-17. Doi: 10.1046/j.1542-474X.2003.08103.x
dc.identifier.doi10.1046/j.1542-474X.2003.08103.xen_US
dc.identifier.endpage17en_US
dc.identifier.issn1082-720Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid12848808en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1542-474X.2003.08103.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18561
dc.identifier.volume8en_US
dc.identifier.wosWOS:000183601500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Futura Publishing, Incen_US
dc.relation.ispartofAnnals of Noninvasive Electrocardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectElectrocardiographyen_US
dc.subjectQT dispersionen_US
dc.subjectSildenafil citrateen_US
dc.titleSildenafil Citrate Does Not Affect Qt Intervals and Qt Dispersion: an Important Observation for Drug Safetyen_US
dc.typeArticleen_US

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