Correlation Between Tissue Lactate Levels and Electroencephalogram In Evaluating the Severity of Experimental Head Trauma

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dc.contributor.authorÖğün, Cemile Öztin
dc.contributor.authorÜstün, Mehmet Erkan
dc.contributor.authorDuman, Ateş
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorGenç, Bülent Oğuz
dc.date.accessioned2020-03-26T16:38:49Z
dc.date.available2020-03-26T16:38:49Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The objective of this study was to develop an electroencephalographic grading scale for evaluating the severity of head trauma and assessing the correlation of this scale with brain tissue lactate concentrations. Design: Animal experiment. Setting: Animal research laboratory in a university hospital. Subjects: Thirty New Zealand rabbits were divided into three groups. Interventions: Rabbits were anesthetized, and bilateral frontoparietal craniectomy was performed. An electroencephalogram was recorded over the dura from both sides. After electroencephalographic recording, unilateral trauma was produced by using the weight drop method with a calculated force of 401) g(.)cm(-1) and 800 g(.)cm(-1) in group 2 (n = 10) and group 3 (n = 10), whereas in group I (n = 10) only craniectomy was performed. Electroencephalographic recording was repeated 60 mins after trauma or craniectomy, and cortical tissue samples were resected from both sides to evaluate tissue lactate concentrations in all three groups. Measurements and Main Results: Electroencephalographic recordings from both sides of the brain were evaluated together by using a 6-point scale (1 = best to 6 = worst) that was based on the presence or absence of electroencephalographic activity and the decrease in amplitude or frequency band of the electroencephalogram. Lactate was measured in resected tissue by using spectrophotometric enzymatic methods. One-way analysis of variance for repeated measures, Bonferroni-adjusted paired Student's t-test, Kruskal Wallis analysis of variance, Bonferroni-adjusted Mann-Whitney-U, and Spearman's correlation tests were used as appropriate for statistical analysis. We considered p < .05 to be significant. The difference in lactate concentrations was significant between the three groups (p < .05). Electroencephalographic grades were significantly different between the pretraumatic and posttraumatic recordings (p < .05) and between the three groups after craniectomy or trauma (p < .001). There was a positive high correlation between lactate concentrations and electroencephalographic grades. Conclusions. Tissue lactate concentrations and electroencephalograhic grades change with the severity of the trauma, and there is a strong positive correlation between tissue lactate concentrations and electroencephalographic grades.en_US
dc.identifier.citationÖğün, C. Ö., Üstün, M. E., Duman, A., Gürbilek, M., Genç, B. O., (2002). Correlation Between Tissue Lactate Levels and Electroencephalogram In Evaluating the Severity of Experimental Head Trauma. Critical Care Medicine, 30(9), 2123-2128. Doi: 10.1097/01.CCM.0000026326.17262.F3
dc.identifier.doi10.1097/01.CCM.0000026326.17262.F3en_US
dc.identifier.endpage2128en_US
dc.identifier.issn0090-3493en_US
dc.identifier.issue9en_US
dc.identifier.pmid12352051en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2123en_US
dc.identifier.urihttps://dx.doi.org/10.1097/01.CCM.0000026326.17262.F3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17913
dc.identifier.volume30en_US
dc.identifier.wosWOS:000178359600027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖğün, Cemile Öztin
dc.institutionauthorÜstün, Mehmet Erkan
dc.institutionauthorDuman, Ateş
dc.institutionauthorGürbilek, Mehmet
dc.institutionauthorGenç, Bülent Oğuz
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCritical Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthead traumaen_US
dc.subjectweight dropen_US
dc.subjectanimal studyen_US
dc.subjectbrain injuryen_US
dc.subjectcortical contusionen_US
dc.subjecttissue lactateen_US
dc.subjectspectrophotometryen_US
dc.subjectelectroencephalographyen_US
dc.subjectgrading scaleen_US
dc.subjectrabbiten_US
dc.titleCorrelation Between Tissue Lactate Levels and Electroencephalogram In Evaluating the Severity of Experimental Head Traumaen_US
dc.typeArticleen_US

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