The Association of Glomerular Filtration Rate and Erectile Dysfunction with Severity of Coronary Artery Disease in Patients Presenting with Chest Pain

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dc.contributor.authorSolak, Yalçın
dc.contributor.authorAkıllı, Hakan
dc.contributor.authorAtalay, Hüseyin
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorGök, Hasan
dc.contributor.authorTürk, Süleyman
dc.date.accessioned2020-03-26T18:05:09Z
dc.date.available2020-03-26T18:05:09Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground The most common cause of death in patients with chronic kidney disease is cardiovascular. Coexistence of reduced estimated glomerular filtration rate (eGFR) and erectile dysfunction (ED) may predate severe underlying coronary artery disease (CAD). The aim of this study was to evaluate the predictive value of presence and severity of ED and reduced estimated eGFR in the risk stratification of CAD in patients with chest pain. Methods Two hundred and sixty-five consecutive male patients with chest pain were included. All patients underwent exercise stress test (EST), of whom those with positive EST underwent coronary angiography. eGFR was calculated and sexual health inventory for men (SHIM) form was applied to evaluate ED. The relation between SHIM scores, eGFR and the number of arteries with significant lesions was evaluated. Results Of the 265 male patients, 105 had positive EST while the remaining 160 patients had negative EST. ED was present in 62 patients (38.8%) in the EST (-) group and in 64 patients (61%) in the EST (+) group (P = 0.000). In the EST (+) group, coronary angiography (CAG) revealed normal coronary anatomy or insignificant coronary lesions in 19 (18%), one-vessel disease in 45 (43%), two-vessel disease in 22 (21%) and three-vessel disease in 19 (18%) patients, respectively. The lowest ED prevalence (36.8%) was seen in patients who had normal coronary anatomy or insignificant coronary lesions while the highest prevalence was in those with three-vessel disease (89.5%). When eGFR were taken into account, there was a significant difference between the groups as well (107.2 +/- 19.2 ml/min in the EST (-) group versus 94.1 +/- 20.0 ml/min in the EST (+) group; P = 0.001). Conclusion The presence and severity of ED and reduced eGFR are associated with the severity of underlying CAD in patients presenting with chest pain, and they could be implemented in the risk stratification of these patients.en_US
dc.identifier.citationSolak, Y., Akıllı, H., Atalay, H., Kayrak, M., Gök, H., Türk, S., (2010). The Association of Glomerular Filtration Rate and Erectile Dysfunction with Severity of Coronary Artery Disease in Patients Presenting with Chest Pain. International Urology and Nephrology, 42(3), 765-771. DOI: 10.1007/s11255-009-9694-y
dc.identifier.doi10.1007/s11255-009-9694-yen_US
dc.identifier.endpage771en_US
dc.identifier.issn0301-1623en_US
dc.identifier.issue3en_US
dc.identifier.pmid20039124en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage765en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-009-9694-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25322
dc.identifier.volume42en_US
dc.identifier.wosWOS:000284910500032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSolak, Yalçın
dc.institutionauthorAkıllı, Hakan
dc.institutionauthorAtalay, Hüseyin
dc.institutionauthorKayrak, Mehmet
dc.institutionauthorGök, Hasan
dc.institutionauthorTürk, Süleyman
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChest Painen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectExercise Stress Testen_US
dc.subjectGlomerular Filtration Rateen_US
dc.titleThe Association of Glomerular Filtration Rate and Erectile Dysfunction with Severity of Coronary Artery Disease in Patients Presenting with Chest Painen_US
dc.typeArticleen_US

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