A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers

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dc.contributor.authorOzarda, Yesim
dc.contributor.authorIchihara, Kiyoshi
dc.contributor.authorAslan, Diler
dc.contributor.authorAybek, Hulya
dc.contributor.authorAri, Zeki
dc.contributor.authorTaneli, Fatma
dc.contributor.authorCoker, Canan
dc.date.accessioned2020-03-26T18:49:11Z
dc.date.available2020-03-26T18:49:11Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (>= 400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and.-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m(2). Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.en_US
dc.description.sponsorshipUludag UniverstyUludag University [UAP(T)-2011/48]; IFCC C-RIDL; Japan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [24256003:2012-2014]; Abbott DiagnosticsAbbott Laboratories; Becton Dickinsonen_US
dc.description.sponsorshipThis study was supported by Research Fund of Uludag Universty (UAP(T)-2011/48), IFCC C-RIDL, Scientific Research Fund (No: 24256003:2012-2014) provided by the Japan Society for the Promotion of Science, Abbott Diagnostics and Becton Dickinson. We had invaluable input from the IFCC C-RIDL and the Turkish National Biochemical Association. We are very grateful to Uludag University Central Laboratory, We are thankful to David Ambruster from Abbott Diagnostics for his kind cooperation to realize this study. The final manuscript was edited with generous support by Prof. A. Myron Johnson.en_US
dc.identifier.doi10.1515/cclm-2014-0228en_US
dc.identifier.endpage1833en_US
dc.identifier.issn1434-6621en_US
dc.identifier.issn1437-4331en_US
dc.identifier.issue12en_US
dc.identifier.pmid25153598en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1823en_US
dc.identifier.urihttps://dx.doi.org/10.1515/cclm-2014-0228
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30548
dc.identifier.volume52en_US
dc.identifier.wosWOS:000345023500026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofCLINICAL CHEMISTRY AND LABORATORY MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbiochemical parametersen_US
dc.subjectcommon reference intervalsen_US
dc.subjectmulticenter studyen_US
dc.subjectregional differencesen_US
dc.subjectTurkeyen_US
dc.titleA multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzersen_US
dc.typeArticleen_US

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