The evaluation of doxorubicin-induced cardiotoxicity: Comparison of Doppler and tissue Doppler-derived myocardial performance index

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dc.contributor.authorAyhan, S. Selim
dc.contributor.authorOzdemir, Kurtulus
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorBacaksiz, Ahmet
dc.contributor.authorVatankulu, M. Akif
dc.contributor.authorEren, Onder
dc.contributor.authorKoc, Fatih
dc.date.accessioned2020-03-26T18:31:44Z
dc.date.available2020-03-26T18:31:44Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Doxorubicin is a chemotherapeutic agent used in a wide spectrum of cancers. However, cardiotoxic effects have limited its clinical use. The early detection of doxorubicin-induced cardiotoxicity is crucial. The purpose of our study was to assess values of Doppler and tissue Doppler imaging (TDI) -derived myocardial performance index (MPI) in adult cancer patients receiving doxorubicin treatment. Methods: A total of 45 patients underwent echocardiographic examinations before any doxorubicin had been administered and then after doxorubicin. Doppler and TDI-derived MPI of left ventricular (LV) were determined in the evaluation of cardiotoxicity. Additionally, TDI-derived MPI of right ventricular (RV) was determined. Results: All patients underwent control echocardiographic examination after mean 5 +/- 1.7 months. The LV MPI obtained by both Doppler and TDI were increased after doxorubicin treatment (0.56 +/- 0.11, 0.61 +/- 0.10, p = 0,005 vs 0.51 +/- 0.09, 0.59 +/- 0.09, p = 0.001, respectively). There was no correlation between Doppler-derived MPI and cumulative doxorubicin dose (coefficient of correlation 0.11, p = 0.6). TDI-derived MPI was correlated with cumulative doxorubicin dose (coefficient of correlation 0.35, p = 0.015), but this correlation is weak (r = 0.38). The study population was divided into two groups according to doxorubicin dose (below and above 300 mg level). There was a moderate correlation between TDI-derived MPI and less than 300 mg of doxorubicin dose (coefficient of correlation 0.51, p = 0.028). However, Doppler-derived MPI was not correlated with less than 300 mg of doxorubicin dose (coefficient of correlation 0.38, p = 0.123). Also, there was no significant change in the TDI-derived RV-MPI (0.49 +/- 0.14, 0.50 +/- 0.12, p = 0.56). Conclusions: TDI-derived MPI is a useful parameter and an early indicator compared with Doppler-derived MPI in the detection of cardiotoxicity during the early stages. Also, doxorubicin administration does not affect RV function. (Cardiol J 2012; 19,4: 363-368)en_US
dc.identifier.doi10.5603/CJ.2012.0066en_US
dc.identifier.endpage368en_US
dc.identifier.issn1897-5593en_US
dc.identifier.issue4en_US
dc.identifier.pmid22825896en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://dx.doi.org/10.5603/CJ.2012.0066
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28525
dc.identifier.volume19en_US
dc.identifier.wosWOS:000309036000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVIA MEDICAen_US
dc.relation.ispartofCARDIOLOGY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdoxorubicinen_US
dc.subjectcardiotoxicityen_US
dc.subjectmyocardial performance indexen_US
dc.titleThe evaluation of doxorubicin-induced cardiotoxicity: Comparison of Doppler and tissue Doppler-derived myocardial performance indexen_US
dc.typeArticleen_US

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