Basal renal function reserve and mean kidney dose predict future radiation-induced kidney injury in stomach cancer patients

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dc.contributor.authorYavas, Guler
dc.contributor.authorElsurer, Rengin
dc.contributor.authorYavas, Cagdas
dc.contributor.authorAta, Ozlem
dc.date.accessioned2020-03-26T18:49:33Z
dc.date.available2020-03-26T18:49:33Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAdjuvant chemoradiotherapy (CRT) improves the survival in patients with locally advanced stomach cancer. The kidneys are the major dose-limiting organs for radiotherapy (RT) in upper abdominal cancers. We aimed to evaluate the impact of adjuvant CRT on renal function of patients with stomach cancer. Fifty-nine stomach cancer patients who underwent postoperative CRT were included. Demographic parameters (age, gender), and basal and 12th-month biochemical parameters were recorded. Mean kidney dose (MKD) administered was determined. Estimated glomerular filtration rate (eGFR) was calculated by modification of diet in renal disease formula. Fifty-nine patients were recruited (age 60.8 +/- 11.9 years; female/male 25/34; follow-up duration 15.6 +/- 9.8 months). Twenty-one patients (35.6 %) had basal eGFR < 90 ml/min/1.73 m(2). When the basal and 12th-month eGFR was compared, eGFR decreased in 27 patients (45.8 %), whereas eGFR remained stable in 32 (54.2 %) patients. Cox regression analyses revealed that a MKD a parts per thousand yen1,500 cGy and basal eGFR < 90 ml/min/1.73 m(2) significantly increased the risk of a decreased eGFR at 12th month (HR = 2.288, 95 % CI 1.009-5.188, p = 0.048 and HR = 2.854, 95 % CI 1.121-7.262, p = 0.028, respectively). MKD a parts per thousand yen1,500 cGy and a basal eGFR < 90 ml/min/1.73 m(2) significantly increased the risk of a decreased eGFR at 12th month. We suggest that patients with stomach cancer be evaluated for their basal renal reserve prior to RT, and it may be more convenient to further minimize the dose to the kidneys with more sophisticated RT techniques in patients with stomach cancer, more specifically in patients with decreased renal reserve.en_US
dc.identifier.doi10.1007/s00520-013-1996-zen_US
dc.identifier.endpage451en_US
dc.identifier.issn0941-4355en_US
dc.identifier.issn1433-7339en_US
dc.identifier.issue2en_US
dc.identifier.pmid24197055en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00520-013-1996-z
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30636
dc.identifier.volume22en_US
dc.identifier.wosWOS:000329372900021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofSUPPORTIVE CARE IN CANCERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlomerular filtration rateen_US
dc.subjectRadiotherapyen_US
dc.subjectRenal functionen_US
dc.subjectStomach canceren_US
dc.titleBasal renal function reserve and mean kidney dose predict future radiation-induced kidney injury in stomach cancer patientsen_US
dc.typeArticleen_US

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