Periodontal treatment of two siblings with juvenile hyaline fibromatosis

Basit Öğe Kaydı
dc.contributor.authorHakki, SS
dc.contributor.authorAtaoglu, T
dc.contributor.authorAvunduk, MC
dc.contributor.authorErdemli, E
dc.contributor.authorGunhan, O
dc.contributor.authorRahman, N
dc.date.accessioned2020-03-26T16:57:41Z
dc.date.available2020-03-26T16:57:41Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and Aim: Juvenile hyaline fibromatosis (JHF) is an autosomal recessive disease that presents with multiple subcutaneous nodular tumours, gingival fibromatosis, flexion contractures of the joint and hyaline material accumulation in extracellular area. Recently, the causative gene for JHF, capillary morphogenesis protein 2 (CMG2) was identified. In this case report, periodontal status, treatment and follow-up together with histopathologic evaluation of gingival tissue specimens and mutation screening of two JHF cases are presented. Case Reports: A 10-year-old female (case 1) and her 3-year-old brother (case 2) were first examined in our department with a complaint of gingival hyperplasia in 1991. Symptoms of the disease were detected in two of four siblings in the family. Several gingivectomy operations were carried out over 11 years with hygiene motivation and initial phase therapy. After the last gingivectomy operation in 2002, the patients were reviewed frequently. Results and Conclusions: Although there was linear marginal gingival inflammation, no remarkable enlargement was noted at last appointment. Histopathological findings showed increased amounts of subepithelial nodular connective tissue, thinned epithelial mucosa, separated inter-cellular bridges and decreased numbers of connective tissue cells in gingival tissue samples. Electron microscopic examinations supported the histopathological findings. Mutation screening of CMG2 demonstrated that the siblings were homozygous for a pathogenic missense mutation, V386F. Our clinical findings demonstrate that gingivectomy is useful and frequent periodontal visits are important for maintaining oral hygiene and decreasing growth rate of gingiva in JHF.en_US
dc.identifier.doi10.1111/j.1600-051X.2005.00760.xen_US
dc.identifier.endpage1021en_US
dc.identifier.issn0303-6979en_US
dc.identifier.issue9en_US
dc.identifier.pmid16104968en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1016en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1600-051X.2005.00760.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19831
dc.identifier.volume32en_US
dc.identifier.wosWOS:000230992400015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofJOURNAL OF CLINICAL PERIODONTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcapillary morphogenesis protein 2en_US
dc.subjectgingivectomyen_US
dc.subjecthistopathologic and electron microscopyen_US
dc.subjectjuvenile hyaline fibromatosisen_US
dc.subjectperiodontal maintenanceen_US
dc.titlePeriodontal treatment of two siblings with juvenile hyaline fibromatosisen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
hakki2005 (2).pdf
Boyut:
3.55 MB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu