Electrocardiographic Findings in Patients with Polycythemia Vera

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dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAcar, Kadir
dc.contributor.authorGul, Enes Elvin
dc.contributor.authorAbdulhalikov, Turyan
dc.contributor.authorBaglicaklioglu, Murat
dc.contributor.authorSonmez, Osman
dc.contributor.authorKaya, Zeynettin
dc.date.accessioned2020-03-26T18:25:26Z
dc.date.available2020-03-26T18:25:26Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The 12-lead surface electrocardiogram (ECG) is a useful tool to predict both atrial and ventricular arrhythmias via P-wave and QT measurements and its derivatives. Polycythemia vera (PV) is a chronic myeloproliferative disorder associated with cardiovascular events. The aim of this study was to assess ECG findings of patients with PV. Method and materials: Sixty patients with PV (34 male, mean age 58 +/- 11 years) and 60 age and gender-matched healthy volunteers were enrolled into the study. From the 12-lead surface ECG, P-wave and both conventional QT measurements and transmyocardial repolarization parameters (T-peak-T-end interval (T-p-T-e) and derivatives) were evaluated digitally by two experienced cardiologists. In addition, a novel parameter, Pi was calculated digitally as the standard deviation of the P-wave duration across the 12 ECG leads. Results: QT duration and corrected QT interval were significantly longer in the PV group compared to healthy controls (p<0.01 and p<0.01, respectively). The T-p-T-e was longer and the T-p-T-e/QT ratio was significantly higher in the PV group compared to the controls. P-wave analyses showed that all P-wave parameters including Pmax, Pmin, P dispersion, and Pi were significantly prolonged in PV patients compared to the controls. The increase of both T-p-T-e and P max in the PV group was independent of age, BMI, diabetes and hypertension, gender, systolic blood pressure, hemoglobin, hematocrit, left atrial dimension, left ventricular end-diastolic diameter and early deceleration time in a univariate analysis of co-variance model (F= 11.097, p= 0.001 and F= 31.537, p= 0.0001, respectively). Conclusion: The present study demonstrated that PV may be associated with electrocardiographic abnormalities of both atrium and ventricle.en_US
dc.identifier.doi10.7150/ijms.9.93en_US
dc.identifier.endpage102en_US
dc.identifier.issn1449-1907en_US
dc.identifier.issue1en_US
dc.identifier.pmid22211096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://dx.doi.org/10.7150/ijms.9.93
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28008
dc.identifier.volume9en_US
dc.identifier.wosWOS:000301065000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIVYSPRING INT PUBLen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPolycythemia Veraen_US
dc.subjectelectrocardiographic abnormalitiesen_US
dc.subjectatriumen_US
dc.subjectventricleen_US
dc.titleElectrocardiographic Findings in Patients with Polycythemia Veraen_US
dc.typeArticleen_US

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