Gender-dependent effects of selenite on the perfused rat heart - A toxicological study

Basit Öğe Kaydı
dc.contributor.authorAyaz, Murat
dc.contributor.authorDalkilic, Nizamettin
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorTuncer, Seckin
dc.contributor.authorDemirel, Ilhami
dc.date.accessioned2020-03-26T17:17:30Z
dc.date.available2020-03-26T17:17:30Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractGender differences are related to the manner in which the heart responds to chronic and acute stress conditions of physiological and pathological nature. Depending on dose, sodium selenite acts as an antioxidant proven to have beneficial effects in several pathological conditions G. Drasch, J. Schopfer, and G. N. Schrauzer, Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and nonsmokers, and relevance to the cancer protective effects of selenium, Biol. Trace Element Res. 103(2), 103-107 (2005); R. G. Kasseroller and G. N. Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review, Am. J. Ther. 7(4), 273-279 (2000); G. N. Schrauzer, Anticarcinogenic effects. of selenium, Cell. Mol. Life Sci. 57(13-14),1864-1873 (2000); I. S. Palmer and O. E. Olson, Relative toxicities of selenite and selenate in the drinking water of rats, J. Nutr. 104(3), 306-314 (1974). To date, little is known about the gender-dependent direct effects of toxic doses of selenite on electrophysiology of the cardiovascular system H. A. Schroeder and M. Mitchener, Selenium and tellurium in rats: effect on growth, survival and tumors, J. Nutr. 101(11), 1531-1540 (1971); G. N. Schrauzer, The nutritional significance, metabolism and toxicology of selenomethionine, Adv. Food Nutr. Res. 47, 73-112 (2003). In the present study, the effects of in vitro toxic concentrations of sodium selenite ranging from 10(-6) M to 10(-3) M were tested on both male and female rat heart preparations. The toxic effects seen in an electrocardiogram and left ventricular pressure were dose and sex dependent aten_US
dc.identifier.doi10.1007/BF02698014en_US
dc.identifier.endpage309en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issue3en_US
dc.identifier.pmid17709910en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage301en_US
dc.identifier.urihttps://dx.doi.org/10.1007/BF02698014
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21415
dc.identifier.volume116en_US
dc.identifier.wosWOS:000247565200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsodium seleniteen_US
dc.subjecttoxicityen_US
dc.subjectgender differenceen_US
dc.subjectleft ventricular pressureen_US
dc.subjectelectrocardiographyen_US
dc.titleGender-dependent effects of selenite on the perfused rat heart - A toxicological studyen_US
dc.typeArticleen_US

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