The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study

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dc.contributor.authorGenc, E.
dc.contributor.authorAvunduk, M. C.
dc.contributor.authorGenc, B. Oguz
dc.contributor.authorSahin, A. Saide
dc.contributor.authorOz, M.
dc.date.accessioned2020-03-26T17:40:37Z
dc.date.available2020-03-26T17:40:37Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective - To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods - Male Sprague-Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test. Results - A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain. Conclusion - Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.en_US
dc.identifier.doi10.1111/j.1600-0404.2008.01153.xen_US
dc.identifier.endpage269en_US
dc.identifier.issn0001-6314en_US
dc.identifier.issue4en_US
dc.identifier.pmid19432933en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1600-0404.2008.01153.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23934
dc.identifier.volume120en_US
dc.identifier.wosWOS:000269861800009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL PUBLISHING, INCen_US
dc.relation.ispartofACTA NEUROLOGICA SCANDINAVICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdipyroneen_US
dc.subjectimmunohistochemical stainingen_US
dc.subjectraten_US
dc.subjectserotonin expressionen_US
dc.subjectsumatriptanen_US
dc.titleThe effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical studyen_US
dc.typeArticleen_US

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