Effect of 1,25 (OH)2D3 Treatment on Glucose İntolerance in Uraemia

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dc.contributor.authorTürk, S
dc.contributor.authorYeksan, M
dc.contributor.authorTamer, N
dc.contributor.authorGürbilek, M
dc.contributor.authorErdoğan, Y
dc.contributor.authorErkul, İ
dc.date.accessioned2020-03-26T16:24:16Z
dc.date.available2020-03-26T16:24:16Z
dc.date.issued1992
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of calcitriol treatment on glucose intolerance in uraemia. Thirty one patients on haemodialysis who had never been treated with vitamin D or related drugs, and 12 healthy control subjects with normal renal functions were studied. Uraemic patients were randomly divided into two groups; 16 patients were treated with oral calcitriol (0.5 mug/day) for 8 weeks, and 15 uraemic patients and 12 healthy subjects were given a placebo. In all these cases, before and 8 weeks after treatment, baseline serum glucose, insulin, calcium, parathormone (PTH), and 1,25 (OH)2D3 were measured. After an oral load of 75 g glucose, blood glucose and insulin were determined at 30, 60, 90, and 120 min. The same measurements were repeated after 8 weeks. HbA1c and fructosamine were also measured at 0 and 8 weeks. Baseline serum insulin was significantly elevated after calcitriol treatment (7.81 versus 11.63 muIU/ml) there was also a significant increase in insulin following calcitriol treatment at 30, 60, 90, and 120 min. On the other hand, glycosylated haemoglobin (HbA1c) and fructosamine decreased after calcitriol treatment (HbA1c 7.09% versus 5.22% P < 0.01 and fructosamine 2.92 versus 2.50 mmol/l P < 0.01). Blood glucose significantly decreased after calcitriol treatment at 0, 30, 60, 90, and 120 min. In the other two groups there were no significant changes in any parameters. These results seem to confirm that vitamin D influences pancreatic beta (beta) cell secretion and suggest that calcitriol may improve glucose intolerance in uraemic haemodialysis patients. This effect of calcitriol is probably due to normalization of serum PTH and regulation of intracellular calcium concentration.en_US
dc.identifier.citationTürk, S., Yeksan, M., Tamer, N., Gürbilek, M., Erdoğan, Y., Erkul, İ., (1992). Effect of 1,25 (OH)2D3 Treatment on Glucose İntolerance in Uraemia. Nephrol Dial Transplant, 7(12), 1207-1212.
dc.identifier.endpage1212en_US
dc.identifier.issn0931-0509en_US
dc.identifier.issue12en_US
dc.identifier.pmid1337161en_US
dc.identifier.startpage1207en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16136
dc.identifier.volume7en_US
dc.identifier.wosWOS:A1992KF47200007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürk, S
dc.institutionauthorYeksan, M
dc.institutionauthorTamer, N
dc.institutionauthorGürbilek, M
dc.institutionauthorErdoğan, Y
dc.institutionauthorErkul, İ
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESS UNITED KINGDOMen_US
dc.relation.ispartofNephrol Dial Transplanten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCALCITRIOLen_US
dc.subjectGLUCOSE INTOLERANCEen_US
dc.subjectHEMODIALYSISen_US
dc.subjectINSULINen_US
dc.subjectUREMIAen_US
dc.titleEffect of 1,25 (OH)2D3 Treatment on Glucose İntolerance in Uraemiaen_US
dc.typeArticleen_US

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