Correlates of Benefit From Neoadjuvant Chemotherapy Before Radiotherapy in Non-small Cell Lung Cancer: A Meta-Analytical Approach With Meta-Regression Analysis

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dc.contributor.authorBozcuk, H.
dc.contributor.authorArtac, M.
dc.contributor.authorÖzdoğan, M.
dc.date.accessioned2020-03-26T17:47:39Z
dc.date.available2020-03-26T17:47:39Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: Induction chemotherapy before radiotherapy, although inferior to concomitant chemoradiotherapy, is still used in clinical practice, and improves survival compared to radiotherapy alone in unresectable non-small cell lung cancer (NSCLC). In this setting, we assessed the predictors of benefit from neoadjuvant chemotherapy before radiotherapy. Methods: Searches were made for randomized clinical trials (RCTs) that compared neoadjuvant chemotherapy with no treatment, administered before definitive radiotherapy. Relative risk (RR) was employed to define the risk of death at 2 and 3 years. Additionally, meta-regression analysis was conducted to explain heterogeneity. Results: Thirteen RCTs to date, encompassing 2776 patients, were identified. In this updated meta-analysis, neoadjuvant chemotherapy significantly reduced the risk of death, both at 2 and 3 years (RR = 0.91 and 0.94, respectively both p < 0.001). Additionally, time to radiotherapy was inversely associated with the benefit from neoadjuvant chemotherapy at 2 (t = 2.20,p = 0.050) and 3 years (t = 1.84, p = 0.093). Conclusion: This meta-analysis confirms the importance of neoadjuvant chemotherapy before radiotherapy and highlights the importance of shorter time to radiotherapy to maximize NSCLC patients 'survival.en_US
dc.identifier.citationBozcuk, H., Artac, M., Özdoğan, M., (2010). Correlates of Benefit From Neoadjuvant Chemotherapy Before Radiotherapy in Non-small Cell Lung Cancer: A Meta-Analytical Approach With Meta-Regression Analysis. Journal of Buon, 15(1), 43-50.
dc.identifier.endpage50en_US
dc.identifier.issn1107-0625en_US
dc.identifier.issue1en_US
dc.identifier.pmid20414926en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24740
dc.identifier.volume15en_US
dc.identifier.wosWOS:000276654500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArtac, M.
dc.language.isoenen_US
dc.publisherZerbinis Medical Publen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectchemotherapyen_US
dc.subjectmeta-analysisen_US
dc.subjectmeta-regressionen_US
dc.subjectneoadjuvanten_US
dc.subjectnon-small cell lung canceren_US
dc.subjectradiotherapyen_US
dc.titleCorrelates of Benefit From Neoadjuvant Chemotherapy Before Radiotherapy in Non-small Cell Lung Cancer: A Meta-Analytical Approach With Meta-Regression Analysisen_US
dc.typeArticleen_US

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