Synthesis and antimicrobial assessment of Fe3+ inclusion complex of p-tert-Butylcalix[4]arene diamide derivative
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
HINDAWI LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Present study deals with the synthesis of the p-tert-butylcalix[4]arene diamide derivative as ligand (L) and its Fe3+ complex, followed by its characterization using TLC and FT-IR, while UV-Vis and Job's plot study were performed for complex formation. Antimicrobial activity of the derivative (L) and its metal complex was carried out by the disc diffusion method against bacteria (Escherichia coli and Staphylococcus albus) and fungi (R. stolonifer). Different concentrations of the derivative (L) (6, 3, 1.5, 0.75, and 0.37 mu g/mL) and its Fe3+ complex were prepared, and Mueller-Hinton agar was used as the medium for the growth of microorganisms. Six successive dilutions of the derivative (L) and Fe3+ complex were used against microorganisms. Two successive dilutions (6 and 3 mu g/mL) of the derivative (L) showed antibacterial action against both Gram-positive and Gram-negative bacteria. In addition, three successive dilutions (6, 3, and 1.5 mu g/mL) of the derivative (L) showed antifungal activity. However, all of six dilutions of the Fe3+ complex showed antimicrobial activity. Derivative (L) showed 3 and 1.5g/mL minimum inhibitory concentrations (MIC) against bacteria and fungi, respectively. On the contrary, its Fe3+ complex showed 0.37g/mL value of MIC against bacteria and fungi. Hence, Fe3+ complex of the derivative (L) was found to be a more effective antimicrobial agent against selected bacteria and fungi than the diamide derivative (L).
Açıklama
Anahtar Kelimeler
Fe3+, p-tert-Butylcalix[4]arene, diamide derivative, Synthesis and antimicrobial assessment
Kaynak
JOURNAL OF CHEMISTRY
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
2019
Sayı
Künye
Chandio, A. A., Ali Memon, A., Memon, S., Memon, F. N., Panhwar, Q. K., Durmaz, F., Nizamani, S. M., Brohi, N. A. (2019). Synthesis and Antimicrobial Assessment of Fe3+ Inclusion Complex of p-tert-Butylcalix [4] arene Diamide Derivative. Journal of Chemistry, 2019, 1-8.
