Evaluation of FDG Uptake in Pulmonary Hila with FDG PET/CT and Contrast-Enhanced CT in Patients with Thoracic and Non-Thoracic Tumors

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dc.contributor.authorKara Gedik, Gonca
dc.contributor.authorÖzcan Kara, Pelin
dc.contributor.authorKara, Taylan
dc.contributor.authorSarı, Oktay
dc.contributor.authorKara, Fatih
dc.date.accessioned2020-03-26T17:48:33Z
dc.date.available2020-03-26T17:48:33Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective Fluorine-18 fluorodeoxyglucose (FDG) uptake is frequently observed in lung hilus. This finding causes difficulties during the interpretation. Our objective was to evaluate the features of FDG uptake in lung hilus associated with benign or malignant etiology in patients with thoracic and non-thoracic tumors. Methods We retrospectively evaluated the files of 1172 patients who had undergone FDG positron emission tomography (PET)/computed tomography (CT) examination between January 2008 and June 2009. Forty-eight patients (21 males, 27 females, age range 12-80 years, mean 60.9 +/- 15.82 years) with either unilateral or bilateral hilar FDG uptake and who had thorax contrast-enhanced computed tomography (CECT) performed within 1 month of the FDG PET/CT scan were enrolled in the study. Characteristics of FDG uptake were classified according to the pathology and CECT or PET/CT follow-up over 12 months. Results The characteristics of 71 hilar regions with FDG uptake could be classified. In 30 of 71 (42.3%) hilar regions, FDG uptake was considered to be physiological because no lymph node was observed on CECT. In 19 of 71 (26.8%), FDG uptake was secondary to benign lymph nodes and in 22 (30.9%) to malignant lymph nodes. Significant differences were observed between benign and malignant lymph nodes for SUVhilus and SUVhilus/SUVliver ratio. Using 4.49 as the cut-off value for SUVhilus, a sensitivity of 85.7% and a specificity of 86.4% were achieved (area under curve, AUC: 0.956). For SUVhilus/SUVliver ratio, sensitivity and specificity to detect malignant lymph nodes were 77.6 and 77.3% (AUC: 0.885), respectively, at a cut-off value of 1.75. Conclusion SUVhilus and SUVhilus/SUVliver ratio were found to be significant parameters for determining malignancy in lung hilus. Combined interpretation with CECT is warranted during the evaluation of lung hilus with FDG PET/CT.en_US
dc.identifier.citationKara Gedik, G., Özcan Kara, P., Kara, T., Sarı, O., Kara, F., (2010). Evaluation of FDG Uptake in Pulmonary Hila with FDG PET/CT and Contrast-Enhanced CT in Patients with Thoracic and Non-Thoracic Tumors. Annals of Nuclear Medicine, (24), 593-599. Doi: 10.1007/s12149-010-0402-x
dc.identifier.doi10.1007/s12149-010-0402-xen_US
dc.identifier.endpage599en_US
dc.identifier.issn0914-7187en_US
dc.identifier.issue8en_US
dc.identifier.pmid20665251en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12149-010-0402-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24903
dc.identifier.volume24en_US
dc.identifier.wosWOS:000283358300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKara Gedik, Gonca
dc.institutionauthorÖzcan Kara, Pelin
dc.institutionauthorSarı, Oktay
dc.institutionauthorKara, Fatih
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectContrast-enhanced computed tomographyen_US
dc.subjectFdgen_US
dc.subjectLung hilusen_US
dc.subjectLymph nodeen_US
dc.subjectPositron emission tomographyen_US
dc.titleEvaluation of FDG Uptake in Pulmonary Hila with FDG PET/CT and Contrast-Enhanced CT in Patients with Thoracic and Non-Thoracic Tumorsen_US
dc.typeArticleen_US

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