Coexistent Familial Nonmultiple Endocrine Neoplasia Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma Associated With RET Polymorphism

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dc.contributor.authorGül, Kamile
dc.contributor.authorÖzdemir, Didem
dc.contributor.authorUğraş, Serdar
dc.contributor.authorİnançlı, Serap S.
dc.contributor.authorErsoy, Reyhan
dc.contributor.authorÇakır, Bekir
dc.date.accessioned2020-03-26T17:47:27Z
dc.date.available2020-03-26T17:47:27Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractFamilial nonmultiple endocrine neoplasia medullary thyroid cancer accounts for 10% to 15% of hereditary medullary thyroid carcinoma and is characterized by lack of accompanying endocrine or nonendocrine diseases. Simultaneous occurrence of medullary and papillary thyroid carcinoma in the same patient is rare and known as collision tumor. Here, the authors present familial nonmultiple endocrine neoplasia medullary thyroid cancer in 4 sisters, all having RET proto-oncogene polymorphism in exon 15 at codon 904 and 2 having additional polymorphism in exon 13 at codon 769. The index case had concomitant medullary and papillary thyroid carcinomas, which are suggested to be completely different tumors in terms of incidence, cell origin, histopathologic features and prognosis. Histopathologically, she also had Hashimoto thyroiditis in the remaining thyroid tissue and medullary thyroid carcinoma metastasis in 3 cervical lymph nodes. This case is the first in the literature to report coexistent familial nonmultiple endocrine neoplasia medullary thyroid cancer and papillary thyroid carcinoma related with a RET polymorphism (S904S in exon 15).en_US
dc.identifier.citationGül, K., Özdemir, D., Uğraş, S., İnançlı, S. S., Ersoy, R., Çakır, B., (2010). Coexistent Familial Nonmultiple Endocrine Neoplasia Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma Associated With RET Polymorphism. American Journal of the Medical Sciences, 340(1), 60-63. Doi: 10.1097/MAJ.0b013e3181dfb245
dc.identifier.doi10.1097/MAJ.0b013e3181dfb245en_US
dc.identifier.endpage63en_US
dc.identifier.issn0002-9629en_US
dc.identifier.issue1en_US
dc.identifier.pmid20463576en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage60en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MAJ.0b013e3181dfb245
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24702
dc.identifier.volume340en_US
dc.identifier.wosWOS:000279638000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUğraş, Serdar
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal of the Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMedullary thyroid carcinomaen_US
dc.subjectPapillary thyroid carcinomaen_US
dc.subjectRearranged during transfection (RET)en_US
dc.subjectPolymorphismen_US
dc.titleCoexistent Familial Nonmultiple Endocrine Neoplasia Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma Associated With RET Polymorphismen_US
dc.typeArticleen_US

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