Is the beneficial effect of preinfarction angina related to an immune response?

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dc.contributor.authorTokaç, Mehmet
dc.contributor.authorÖzdemir, Ayşe
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorAltunkeser, Bülent Behlül
dc.contributor.authorDüzenli, Akif
dc.contributor.authorReisli, İsmail
dc.contributor.authorÖzdemir, Kurtuluş
dc.date.accessioned2020-03-26T16:55:20Z
dc.date.available2020-03-26T16:55:20Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractImmune-mediated mechanisms are thought to play a key role in the,development of coronary artery disease and its thrombotic complications. Preinfarction angina has been suggested to improve left ventricular function and short-term outcomes. The purpose of the present study was to investigate the relation between the immune response and in-hospital clinical course in preinfarction angina. We prospectively evaluated 93 patients. Forty-three patients exhibited. preinfarction angina within 24 hours before the onset of acute myocardial infarction (AMI) (preinfarction angina group) and 50 patients were free from preinfarction angina (sudden onset group). The incidence of complications (heart failure, recurrent angina, arrhythmia and coronary interventions) and in-hospital mortality were assessed in the two study groups. We detected some immune markers, including white blood cells, C-reactive protein, immunoglobulins, and complement. White blood cells and CRP were significantly lower in the preinfarction angina group than in the sudden onset group (P < 0.001, P < 0.005, respectively). Conversely, IgE and C-4 were significantly higher in the preinfarction angina group than in the sudden onset group (P < 0.001, P < 0.001, respectively). The incidences of heart failure and severe arrhythmias were lower in the preinfarction group than in the Sudden onset group (P < 0.005, P < 0.05 respectively). The beneficial effect of preinfarction angina may be associated with an immune-inflammatory response modified by a brief ischemic episode.en_US
dc.identifier.doi10.1536/jhj.45.205en_US
dc.identifier.endpage215en_US
dc.identifier.issn0021-4868en_US
dc.identifier.issue2en_US
dc.identifier.pmid15090697en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://dx.doi.org/10.1536/jhj.45.205
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19110
dc.identifier.volume45en_US
dc.identifier.wosWOS:000221490800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MEDen_US
dc.relation.ispartofJAPANESE HEART JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectimmune responseen_US
dc.subjectpreinfarction anginaen_US
dc.subjectcomplementen_US
dc.subjectIgEen_US
dc.subjectCRPen_US
dc.titleIs the beneficial effect of preinfarction angina related to an immune response?en_US
dc.typeArticleen_US

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