Novel Bioactive Vic-Dioxime Ligand Containing Piperazine Moiety: Synthesis, X-ray Crystallographic Studies, 2D NMR Applications and Complexation With Ni(II)
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A new vic-dioxime ligand bearing an important pharmacophore substituent, anti-1-(4-benzylpiperazine-1-yl) phenylglyoxime (LH2) (Scheme 1), has been synthesized and its nickel(II) complex was obtained by the reaction of NiCl2 center dot 6H(2)O and the ligand. The characterization of the newly formed compounds was performed by elemental analysis, FT-IR, 1D NMR (H-1, C-13, DEPT), 2D NMR (HMBC), ESI mass-spectrometry, TG/DTA, X-ray crystallography. The antibacterial activity was also studied against Staphylococcus aureus ATCC 25923, Streptococcus mutans RSHM 676, Enterococcus faecalis ATCC 29212, Lactobacillus acidophilus RSHM 06029, Escherichia coli ATCC 25922, E. coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853. The antimicrobial test results indicated that all the compounds have mild antibacterial activity against both Gram negative and Gram positive bacterial species.
Açıklama
Anahtar Kelimeler
vic-Dioxime, Nickel(II) complexes, Piperazine moiety, ID and 2D NMR, Crystal structure, Antimicrobial activity
Kaynak
Polyhedron
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
29
Sayı
Künye
Yılmaz, A., Taner, B., Deveci, P., Obalı, A. Y., Arslan, U., Şahin, E., Uçan, H. İ., (2010). Novel Bioactive Vic-Dioxime Ligand Containing Piperazine Moiety: Synthesis, X-ray Crystallographic Studies, 2D NMR Applications and Complexation With Ni(II). Polyhedron, (29), 2991-2998. Doi: 10.1016/j.poly.2010.08.006
